fbpx Skip to main content

Rarely, some individuals may develop symptoms of alopecia areata following COVID-19 infection or vaccination, which are associated with pro-inflammatory cytokines that are also implicated in the pathogenesis of alopecia areata.

Alopecia areata (AA) concerns have emerged following COVID-19 vaccination and infection. This cross-sectional analysis evaluated the relationship between COVID-19 infection or vaccination and AA. The study concluded that, rarely, certain individuals might exhibit symptoms of AA following COVID-19 vaccination or infection. These symptoms are associated with certain pro-inflammatory cytokines that are commonly seen in AA pathogenesis. The study also concluded that psychological stress associated with the pandemic might exacerbate AA. The study findings are published in the Journal of the European Academy of Dermatology and Venereology.

Majority of AA Symptoms Following COVID-19 Infection Represented New Onset of AA

Symptoms of AA after COVID-19 infection or vaccination occurred in 42.4% and 68.1% of the study participants, respectively. In the former group, 60% of the symptoms represented new onset AA diagnosis, whereas 36% of the symptoms represented relapse of pre-existing AA. The mean (SD) onset of specified AA symptoms was 50.6 (31.7) days following infection. Regarding AA symptoms after COVID-19 vaccination, new-onset AA diagnosis accounted for 50.6% and relapse of pre-existing AA accounted for 49.4%. The mean (SD) onset of specified AA symptoms was 61.5 (72.7) days.

The Development of AA Is Associated With Pro-Inflammatory Cytokines

The potential mechanism underlying the temporal association between the appearance of symptoms of AA and COVID-19 vaccination or infection is the upregulation of pro-inflammatory cytokines, including interferon-gamma (IFN-γ), interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-α). These pro-inflammatory cytokines are also implicated in the pathogenesis of AA. Psychological stress associated with the pandemic may also exacerbate AA.

You May Also Like::  Here's What You Need To Know About Psoriasis With Dr. Hope Mitchell

The Study May Have Potential Response and Sampling Bias

The data collected in this cross-sectional analysis was acquired via online support groups in the form of patient-reported information. Therefore, the study may have potential response and sampling bias. Additionally, the relapsing and remitting nature of AA may result in coincidental occurrence of symptoms in association with COVID-19 infection and/or vaccination.

This cross-sectional study demonstrated that some individuals who experienced COVID-19 infection or vaccination might experience new-onset or relapsing symptoms of AA. This may be associated with pandemic-related psychological stress and pro-inflammatory cytokines.

Source

Nguyen, B., & Tosti, A. (2023). Alopecia areata after COVID-19 infection and vaccination: A cross-sectional analysis. J Eur Acad Dermatol Venereol, 37(1), e7-e8. https://doi.org/10.1111/jdv.18491

 

“Keeping up with the indications and adverse reactions to immune checkpoint inhibitors can be a full-time job. Cutaneous side effects occur in up to 45% of patients treated with ipilimumab and 34% of patients treated with nivolumab and pembrolizumab.” https://bit.ly/3FGtxtd

.@spfnomt: This month’s #DermWorld article “Estate planning 101” is especially important for young physicians to read. The long, all-consuming years between adolescence and physicianhood can become a blur...https://bit.ly/3FxOtCv

That’s a wrap #AAD2023! 5 days of soaking up knowledge from dermatologists on topics such as hidradenitis, melasma, & dietary triggers of common dermatoses.

I LOVED the #womenshealth focused sessions on vulvar dermatoses and pregnancy medication safety.

#dermtwitter
@AADmember

New approach uses microbiome to treat skin disease by repairing the injured microbiome that allowed inflammation to flare up in the first place, rather than reducing the inflammation after the fact. https://bit.ly/3Jt6H9v

Load More