Condition Center

Salvianolic acid A, an anti-cancer agent, showed a potential effect on M2 tumor-associated macrophages in a cell culture study, which concluded that it may be useful for reprogramming these macrophages in the management of triple-negative breast cancer. Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with challenging management and a poor prognosis....

A nurse-led strategy effectively reduced blood pressure and cholesterol levels in people with HIV in a randomized trial. People with HIV (PWH) have a higher atherosclerotic cardiovascular disease risk, but they face unique barriers to its prevention, such as changing models of HIV primary care. A randomized clinical trial published in JAMA Network Open evaluated...

Exercise training and diet therapy improved physical fitness and salivary testosterone levels in an interventional study of people living with HIV/AIDS. Acquired immune deficiency syndrome (AIDS) is caused by the human immunodeficiency virus (HIV). Exercise and nutrition constitute important components of treatment protocols and rehabilitation care for people living with HIV/AIDS (PLWHA). However, no thorough...

Bimekizumab demonstrates overall greater efficacy than guselkumab in psoriatic arthritis patients at 52 weeks, according to an analysis of data from several trials. Approximately 30% of psoriasis patients develop psoriatic arthritis (PsA). Recent Phase 3 trials have demonstrated the efficacy and safety of bimekizumab (an interleukin-17F and IL-17A inhibitor) and guselkumab (an interleukin-23 inhibitor) in...

A phase 3 study of risankizumab finds durable long-term efficacy and a stable safety profile in patients with active psoriatic arthritis. Psoriatic arthritis (PsA) affects approximately 0.05–0.25% of the general population and 6–41% of psoriasis patients. As most PsA patients do not maintain minimal disease activity on current therapies, there is a need for effective...

A phase II trial confirms the efficacy and safety of frexalimab and its ability to reduce disease activity in patients living with relapsing MS, with considerable benefit compared to placebo. The CD40–CD40L (CD154) costimulatory pathway, which regulates adaptive and innate immune responses, has been implicated in the pathogenesis of multiple sclerosis (MS). Elevated levels of...

A new preclinical study in an animal model found that stem cells and stem cell-derived exosomes may benefit those living with multiple sclerosis. The study found exomes as a promising emerging therapy with a better safety profile. Multiple sclerosis (MS) is a debilitating autoimmune disease characterized by the progressive destruction of myelin. This demyelination leads...

Results of a phase 2 study indicate that bipolar androgen therapy with nivolumab may augment the anti-tumor immunologic response of the body against metastatic castration-resistant prostate cancer, which is further strengthened by immune checkpoint inhibition. Bipolar androgen therapy (BAT) in metastatic castration-resistant prostate cancer (mCRPC) patients drives testosterone levels above the physiologic range and then...

A randomized controlled trial found that nomograms based on multiple Cox regression models could effectively predict the risk factors associated with overall survival and cancer-specific survival in patients with localized prostate cancer as well as assess survival differences between surgery and radiotherapy.  Prostate cancer affects a substantial proportion of men across the globe, with more...