Condition Center

In the fight against HIV, a computer projection model finds that offering pre-exposure prophylaxis through community-based methods shows promise for reaching more people.  A modeling study was carried out to find ways to make pre-exposure prophylaxis (PrEP) more accessible by integrating HIV self-testing. While self-testing allows people to check their HIV status privately, there’s concern...

The detection of opportunistic infections in individuals newly diagnosed with HIV serves as an indicator of the gaps in awareness and timely testing for HIV.  Global initiatives have significantly enhanced early HIV detection. However, despite the strides, in many parts of the world, late diagnosis and the prevalence of opportunistic infections persist.   A retrospective study...

An analysis of microarray data demonstrated impaired apoptosis signaling pathways in CD14+ monocytes in psoriatic arthritis patients, concluding that their increased levels may play an essential role in the disease pathogenesis. Psoriatic arthritis (PsA) is a complex chronic inflammatory condition affecting approximately 30% of patients with psoriasis, leading to functional impairments and increased mortality risk. ...

A prospective follow-up study found that psoriatic arthritis patients with higher synovial immunohistochemical reactivity of IL-17A, DKK1, and TGF-β1 are more likely to benefit from early initiation of biologics. Psoriatic arthritis (PsA) is a chronic inflammatory disease affecting joints and skin in patients with psoriasis. It exhibits progressive and destructive joint changes, with significant pathological...

Although psoriatic arthritis activity indices might suggest disease severity, this retrospective study demonstrated that disease activity levels and severity are two different concepts and not essentially interchangeable. Psoriatic arthritis (PsA) is a complex, chronic, multidomain inflammatory disease. There have been many studies and indices focusing on identifying and classifying disease activity levels. However, much less...

Salvianolic acid A, an anti-cancer agent, showed a potential effect on M2 tumor-associated macrophages in a cell culture study, which concluded that it may be useful for reprogramming these macrophages in the management of triple-negative breast cancer. Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with challenging management and a poor prognosis....

A nurse-led strategy effectively reduced blood pressure and cholesterol levels in people with HIV in a randomized trial. People with HIV (PWH) have a higher atherosclerotic cardiovascular disease risk, but they face unique barriers to its prevention, such as changing models of HIV primary care. A randomized clinical trial published in JAMA Network Open evaluated...

Exercise training and diet therapy improved physical fitness and salivary testosterone levels in an interventional study of people living with HIV/AIDS. Acquired immune deficiency syndrome (AIDS) is caused by the human immunodeficiency virus (HIV). Exercise and nutrition constitute important components of treatment protocols and rehabilitation care for people living with HIV/AIDS (PLWHA). However, no thorough...

Bimekizumab demonstrates overall greater efficacy than guselkumab in psoriatic arthritis patients at 52 weeks, according to an analysis of data from several trials. Approximately 30% of psoriasis patients develop psoriatic arthritis (PsA). Recent Phase 3 trials have demonstrated the efficacy and safety of bimekizumab (an interleukin-17F and IL-17A inhibitor) and guselkumab (an interleukin-23 inhibitor) in...