Hodgkin Lymphoma

Although FDG-PET imaging is the gold standard for interim response assessment in patients with classic Hodgkin lymphoma, this technique cannot be performed frequently. This study, published in the Journal of Extracellular Vesicles, examined a minimally invasive way to assess tumor presence and burden using microRNA (miRNA) associated with tumor-secreted extracellular vesicles (EV). The study included 193...

Among the biomarkers of classic Hodgkin lymphoma are tissue and soluble markers involved in the programmed cell death protein 1/programmed death-ligand (PD-1/PD-L) axis. This study, published in the British Journal of Haematology, sought to determine whether or not plasma levels of proteins in the PD-1/PD-L axis reflect expressions by corresponding tissue.  The researchers collected paired tissue...

Hodgkin lymphoma is typically centered around the cervical, supraclavicular, and mediastinal lymph nodes. Although involvement of the central nervous system has been documented, it is extremely rare. This case study, published in the Journal of Medical Case Reports, analyzed one of these cases of extranodal Hodgkin lymphoma in the central nervous system.  The patient in this...

A study, published in Blood, on the role of gut microbiota (GM) in response to chemo-immunotherapeutic agents in patients with relapsed/refractory (R/R) B-cell lymphoma will be presented at the 2021 ASH Annual Meeting & Exposition.  Over three years, the researchers collected data from a cohort of 17 patients with R/R classic Hodgkin lymphoma (cHL) or...

One of the studies that will be presented at the 2021 ASH Annual Meeting & Exposition is a retrospective study, published in Blood, on the efficacy of the COVID-19 vaccines in adult patients with lymphomas undergoing immunochemotherapy. Data were gathered from adult patients with lymphomas identified to have received the COVID-19 vaccine, either two doses...

This study, published in Blood, highlights the limited data on epidemiologic factors that impact immune profiles of patients with hematologic malignancies. The study’s flow cytometric analyses of different hematologic malignancy immune panels with regard to age, race, and sex will be presented at the 2021 ASH Annual Meeting & Exposition. Flow cytometric analyses of immune panels including...

Findings from the expansion of a phase 1 study of tinostamustine in patients with relapsed/refractory (R/R) Hodgkin Lymphoma (HL) will be presented at the 2021 ASH Annual Meeting & Exposition. Tinostamustine is a developing therapy designed to improve drug access to DNA strands, induce DNA damage, and counteract DNA repair in cancer cells. A dose-escalation study...

What can clinicians do to continue treating patients with Hodgkin’s lymphoma (HL) during a widespread shortage of the drugs typically used to do so? This study, published in Blood, reviewed this predicament experienced by hematologists/oncologists in Mexico from mid-2019 to mid-2021. The study will be presented at the 2021 ASH Annual Meeting & Exposition.  During the drug...

Classic Hodgkin lymphoma can usually be treated successfully in younger patients using ABVD (Adriamycin, bleomycin, vinblastine, and dacarbazine). However, older patients with the disease have a relatively poor prognosis, and ABVD’s efficacy and tolerability in this population are uncertain. This retrospective study, published in Internal Medicine, analyzed the outcomes of older patients with classic Hodgkin lymphoma treated...