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The deregulation of ubiquitin-specific protease 7 activity increased DNA replication stress in an in vitro study, which was found to disrupt the DNA repair process during the S phase of the cell cycle. Aberrant expression of ubiquitin-specific protease 7 (USP7), a deubiquitinating enzyme, is involved in tumor progression. This is due to altered DNA damage...

Saraca asoca methanol bark extract had a selective anticancer effect on the estrogen-receptor subtype of triple-negative breast cancer in a cell culture study. The anticancer effects were attributed to phytoestrogens in the methanol bark extract, particularly quercetin. Saraca asoca has been found to have anticancer effects related to the presence of phytoestrogens in the methanol...

17ß-estradiol promotes metastasis in patients with triple-negative breast cancer. A cell culture and mouse model study demonstrated that this process may be mediated by the calpain/YAP/ß-catenin signaling axis. The absence of estrogen and progesterone receptors and human epidermal growth factor receptor-2 characterizes triple-negative breast cancer (TNBC) cells. The estrogen 17ß-estradiol, or E2, promotes the proliferation...

The type of adjuvant systemic therapy has an impact on Edmonton Symptom Assessment System scores in patients with breast cancer, as reported in a recent retrospective analysis. Triple-negative tumor histology and the outcomes of previous neoadjuvant treatment were related to symptom burden. Multimodal treatment in breast cancer patients can have side effects, as reported in...

Increased mortality risks seen for five major adverse pregnancy outcomes; further increases seen with multiple adverse outcomes Women who experience any of five major adverse pregnancy outcomes have increased mortality risks, which remain elevated during long-term follow-up, according to a study published online April 15 in JAMA Internal Medicine. Casey Crump, M.D., Ph.D., from the University...

Incidence rate ratios as high as 14.2 among American Indian or Alaska Native females compared with non-Hispanic Whites Persistent disparities by race/ethnicity are seen in the incidence of tuberculosis (TB), according to a study published online April 2 in the Annals of Internal Medicine. Yunfei Li, Sc.D., from the Harvard T.H. Chan School of Public Health...

Causal relationship seen for moderately severe anxiety group with increased GERD incidence Anxiety and depression are associated with an increased incidence of gastroesophageal reflux disease (GERD), according to a study published online March 19 in Scientific Reports. Qian Li, from The Third People’s Hospital of Chengdu in China, and colleagues gathered 24-hour pH monitoring data and...

Authors say sharp increase in cardiovascular risk warrants more regular screening Postmenopausal changes may accelerate coronary artery calcium (CAC) progression in women, according to a study presented at the annual meeting of the American College of Cardiology, held from April 6 to 8 in Atlanta. Ella Ishaaya, M.D., from Harbor-UCLA Medical Center in Torrance, California,...

A patient survey study confirms that food allergies impose a significant psychosocial burden on patients and their caregivers. Food allergies exert a substantial negative impact on the mental, emotional, and social well-being of patients and their caregivers. Patients and caregivers often experience anxiety related to food allergies.  A prospective study published in the World Allergy...