Specialty

A phase II trial confirms the efficacy and safety of frexalimab and its ability to reduce disease activity in patients living with relapsing MS, with considerable benefit compared to placebo. The CD40–CD40L (CD154) costimulatory pathway, which regulates adaptive and innate immune responses, has been implicated in the pathogenesis of multiple sclerosis (MS). Elevated levels of...

A new preclinical study in an animal model found that stem cells and stem cell-derived exosomes may benefit those living with multiple sclerosis. The study found exomes as a promising emerging therapy with a better safety profile. Multiple sclerosis (MS) is a debilitating autoimmune disease characterized by the progressive destruction of myelin. This demyelination leads...

Bifidobacterium-dominant module and IgE levels specific to milk and casein were associated with the acquisition of sustained unresponsiveness to cow’s milk allergy in participants on oral immunotherapy in a randomized cohort study. Oral immunotherapy can improve cow’s milk allergy (CMA); however, it is challenging to maintain unresponsiveness to allergens. The gut microbiome and fecal water-soluble...

Interventions in health offerings and allergenic food management that shifted towards  Mediterranean dietary patterns were found to be effective for improving the quality of restaurant menus. In recent decades, there has been a rise in the consumption of restaurant meals, due to work, study, and leisure commitments. Restaurants can be potential targets for interventions in...

Results of a phase 2 study indicate that bipolar androgen therapy with nivolumab may augment the anti-tumor immunologic response of the body against metastatic castration-resistant prostate cancer, which is further strengthened by immune checkpoint inhibition. Bipolar androgen therapy (BAT) in metastatic castration-resistant prostate cancer (mCRPC) patients drives testosterone levels above the physiologic range and then...

A randomized controlled trial found that nomograms based on multiple Cox regression models could effectively predict the risk factors associated with overall survival and cancer-specific survival in patients with localized prostate cancer as well as assess survival differences between surgery and radiotherapy.  Prostate cancer affects a substantial proportion of men across the globe, with more...

A nurse-led mobile-based health coaching program promoted positive lifestyle changes that improved various parameters of metabolic syndrome in prostate cancer patients. Prostate cancer patients are prone to adverse metabolic changes that stem from the physical effects of androgen deprivation therapy (ADT). These changes include body fat accumulation and abnormal fasting glucose levels, with subsequent development...

A retrospective cohort study finds that multimodal radiomics and pathomics based on deep learning algorithms are useful tools for predicting the risk of bone metastases in patients diagnosed with primary prostate cancer. Bone metastasis is a common consequence of disease progression in primary prostate cancer patients and plays an important role in the morbidity and...

Secondary analysis of a prospective trial finds that while repeated screening for prostate cancer is crucial to the detection of pathology, the proportion of magnetic resonance imaging scans that prompt suspicion of cancer is relatively low. Prostate cancer screening with prostate-specific antigen (PSA) plays a pivotal role in decreasing cancer-related mortality. Screening with PSA testing...