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As wet age-related macular degeneration (AMD) progresses, choroidal thickening is hypothesized to occur. However, some studies also report choroidal thinning in eyes with wet AMD. This study, published in QJM: An International Journal of Medicine, sought to clarify the relationship between choroidal thickness and choroidal neovascularization using spectral-domain optical coherence tomography.

The study used data from 33 eyes of 30 patients with wet AMD and an age-matched control group. A complete ocular history and physical exam were performed. Central foveal thickness and subfoveal choroidal thickness were measured using spectral-domain optical coherence tomography. 

Ultimately, a significant decrease in subfoveal choroidal thickness was found to be present in the group with wet AMD. No significant difference in subfoveal choroidal thickness was found between cases of active and inactive choroidal neovascularization [1].


[1] Abouelregal, A. R., Mahmoud, A. F., Eliwa, T. F., & Naguib, K. M. (2021). Correlation between subfoveal choroidal thickness and disease activity in wet age-related macular degeneration using spectral domain optical coherence tomography. QJM: An International Journal of Medicine, 114(Supplement_1). https://doi.org/10.1093/qjmed/hcab109.003

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