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Midwall fractional shortening trajectories differ by race from early age to young adulthood

Black individuals have a greater decrease in midwall fractional shortening (MFS) compared with Whites, with trajectories for race differing from early age to young adulthood, according to a study published in the Feb. 2 issue of the Journal of the American Heart Association.

Gaston Kapuku, M.D., Ph.D., from Augusta University in Georgia, and colleagues assessed 673 individuals during a period of 30 years to examine whether the Black population has decreased myocardial function compared to the White population. Similar percentages of Black and White participants were included. MFS was used to probe left ventricular systolic function.

The researchers found that compared with White participants, Black participants had greater body mass index, higher blood pressure readings, and greater left ventricular mass. Compared with White participants, Black participants had a 0.54 percent decrease in MFS. There was a 0.05 percent increase in MFS with each one-year increase in age. MFS decreased by 0.01 percent as left ventricular mass increased by 1 g. There was a 0.04 percent decrease in MFS with each one-unit increase in circumferential end systolic stress. From early age to young adulthood, the MFS trajectories differed by race.

“Our findings support an important role of cardiac load on myocardial function trajectories from childhood to early adulthood,” the authors write. “Our findings call for earlier intervention to curb the epidemic of heart failure in populations at high cardiovascular risk, such as Black participants.”

Abstract/Full Text

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