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Toleriane, a dermo-cosmetic, is effective for eyelid eczema.

Eyelid eczema (EE) is clearly defined clinically and medically, yet it remains a complex pathology. In addition to its frequent resistance to medication and susceptibility to relapse, dermatologists and ophthalmologists find its diagnosis and management challenging.

Toleriane, a dedicated dermo-cosmetic (DC), was formulated to reestablish the periocular region’s skin barrier and reduce signs and symptoms of EE. Toleriane contains niacinamide, fractions of the probiotic Sphingobium, and Neurosensine®, a calming substance that reduces skin sensitivity by alleviating the erythema, itching, and irritation that are frequently observed in periorbital eczema.

These findings are reported in a study conducted in Batumi, Georgia, and published in Clinical, Cosmetic and Investigational Dermatology.

Toleriane Immediately Reduced Symptoms

Within 10 minutes of the initial application Toleriane reduced the level of itching, prickling, tightness, and burning sensations by an average of one point on a five-point scale. Clinical indicators, including desquamation, eczematide, erythema, palpebral edema, and roughness, as assessed by dermatologists, and symptoms recorded by subjects, improved considerably on Day 14 and were maintained through Day 28.

Improvement Was Seen on Day 28 of Treatment With Toleriane

At Day 28 (T10), the percentage of participants with Day 0 desquamation had reduced to 46%; those with eczema had decreased to 18%; those with erythema had declined to 51%; those with palpebral edema had decreased to 59%; and those with roughness had decreased to 13%. Similarly, by Day 28, the proportion of patients who reported itching on Day 0 had reduced to 64%, those reporting prickling to 26%, those reporting heat/burn sensations to 18%, and those reporting tightness to 23%.

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The Use of Specially Formulated Dermo-Cosmetics Is Recommended for Eyelid Eczema

Periorbital skin is delicate and requires special care; using specially formulated dermo-cosmetics is recommended for eczema treatment as it can help preserve or restore the natural skin barrier and reduce symptoms of eczema. These products should be free of known allergens, well-tolerated, and not cause additional side effects.

Toleriane, the currently evaluated periorbital DC, proved effective and did not produce any dermatological or ophthalmological side effects, fulfilling all standards for a periorbital DC.


Tan, J., Demessant, A. L., Le Dantec, G., Le Floc’h, C., & Kerob, D. (2023). Tolerance and Efficacy of a Dermocosmetic Containing Neurosensine® in Subjects with Eyelid Eczema. Clinical, Cosmetic and Investigational Dermatology, 161-165. https://doi.org/10.2147/CCID.S391890

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