fbpx Skip to main content

Nonmodifiable risk factors include gestational diabetes, maternal history of allergy, prenatal history of eczema

Genetic and environmental prenatal risk factors play a role in early childhood atopic dermatitis (AD), according to a review published online Jan. 27 in the Annals of Dermatology.

Hong Cui, M.D., Ph.D., from the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine and Zhijuan Mu, from the National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, both in Tianjin, China, conducted a systematic review and meta-analysis of 27 cohort studies to examine the association between modifiable and nonmodifiable gestational and prenatal risk factors that affect AD prevalence in children.

The researchers found that gestational diabetes, maternal history of allergy, and prenatal history of eczema (odds ratios, 7.2, 2.14, and 2.46, respectively) were major determining nonmodifiable risk factors in early manifestation of AD in children. Leading causes of early AD manifestation also included maternal exposure to industrial products, exposure to antibiotics during pregnancy, and passive smoking during pregnancy (odds ratios, 1.89, 3.59, and 2.60, respectively).

“Both genetic and environmental factors play a pivotal role in early manifestation of AD,” the authors write. “Further studies are required [to] clarify the mechanisms and ways to manage the modifiable factors to the least.”

Abstract/Full Text

You May Also Like::  FDA Approves New Two-Drug Combo Medicine for Asthma

“Keeping up with the indications and adverse reactions to immune checkpoint inhibitors can be a full-time job. Cutaneous side effects occur in up to 45% of patients treated with ipilimumab and 34% of patients treated with nivolumab and pembrolizumab.” https://bit.ly/3FGtxtd

.@spfnomt: This month’s #DermWorld article “Estate planning 101” is especially important for young physicians to read. The long, all-consuming years between adolescence and physicianhood can become a blur...https://bit.ly/3FxOtCv

That’s a wrap #AAD2023! 5 days of soaking up knowledge from dermatologists on topics such as hidradenitis, melasma, & dietary triggers of common dermatoses.

I LOVED the #womenshealth focused sessions on vulvar dermatoses and pregnancy medication safety.


New approach uses microbiome to treat skin disease by repairing the injured microbiome that allowed inflammation to flare up in the first place, rather than reducing the inflammation after the fact. https://bit.ly/3Jt6H9v

Load More