fbpx Skip to main content

Myelodysplastic syndromes (MDS) have been challenging to develop treatments for, partially due to insufficient recruitment in clinical trials. The factors underlying this low recruitment have not been well understood. This study, published in Cancer, compared patients with MDS that enrolled in intervention trials with those who did not. The study’s goal was to obtain a more robust understanding of the characteristics and demographic factors common to each group. 

This study used data from the U.S. MDS Clinical Research Consortium. The data were gathered from 1,919 patients with MDS. Of these patients, 23% participated in an intervention trial. The researchers found that 64% of the trial participants were male, with a median age of 68. Overall, patients who participated in trials were more likely to be younger and male. Although race was not correlated significantly with trial participation, living in a wealthier zip code was. 

Researchers also found that trial participation correlated with a reduced hazard of death. Despite this finding, a small minority of patients were found to participate in trials. Among the factors that limit enrollment in these trials, the researchers identified age restrictions, comorbidities, and past cancer history as the main factors. They note that more research is needed to determine how future investigators can recruit a more diverse cohort of trial participants with MDS [1].

Source:

[1] Brierley, C. K., Zabor, E. C., Komrokji, R. S., DeZern, A. E., Roboz, G. J., Brunner, A. M., Stone, R. M., Sekeres, M. A., & Steensma, D. P. (2020). Low participation rates and disparities in participation in interventional clinical trials for myelodysplastic syndromes. Cancer, 126(21), 4735–4743. https://doi.org/10.1002/cncr.33105

You May Also Like::  Why Black Representation Matters in Clinical Trials

“Keeping up with the indications and adverse reactions to immune checkpoint inhibitors can be a full-time job. Cutaneous side effects occur in up to 45% of patients treated with ipilimumab and 34% of patients treated with nivolumab and pembrolizumab.” https://bit.ly/3FGtxtd

.@spfnomt: This month’s #DermWorld article “Estate planning 101” is especially important for young physicians to read. The long, all-consuming years between adolescence and physicianhood can become a blur...https://bit.ly/3FxOtCv

That’s a wrap #AAD2023! 5 days of soaking up knowledge from dermatologists on topics such as hidradenitis, melasma, & dietary triggers of common dermatoses.

I LOVED the #womenshealth focused sessions on vulvar dermatoses and pregnancy medication safety.

#dermtwitter
@AADmember

New approach uses microbiome to treat skin disease by repairing the injured microbiome that allowed inflammation to flare up in the first place, rather than reducing the inflammation after the fact. https://bit.ly/3Jt6H9v

Load More