Among the available biomarkers for age-related macular degeneration (AMD) is delayed dark-adapted vision recovery. However, its use is burdensome for both patients and examiners. This study, published in Eye and Brain, sought to determine the utility of a novel portable system in measuring dark-adapted visual evoked potentials (DAVEP), a metric for delayed dark-adapted vision recovery.
The portable system is wireless and requires a headset and smartphone to deliver photo-bleach and monocular pattern reversal stimuli. It also uses electroencephalography electrodes to measure DAVEP separately at the peripheral and central visual fields. Sessions take 20 minutes and do not require subject reporting.
A DAVEP1 score was measured for 12 patients with AMD and 8 controls. Ultimately, it was found that 90% of patient eyes were correctly classified, with at least one eye of each patient with AMD identified. The researchers concluded that their novel device could facilitate the measurement of delayed dark-adapted vision recovery and the early diagnosis of AMD .
Source: Versek, C., Banijamali, S. M. A., Bex, P., Lashkari, K., Kamarthi, S., & Sridhar, S. (2021). Portable diagnostic system for age-related macular degeneration screening using visual evoked potentials. Eye and Brain, 13, 111–127. https://doi.org/10.2147/eb.s295745