fbpx Skip to main content

Black residents accounted for 2.9 percent of participants in clinical trials for cardiovascular drugs approved by the FDA from 2006 to 2020

Black residents are underrepresented as participants in clinical trials to support the approval of cardiovascular drugs in the United States, according to a research letter published online March 23 in JAMA Network Open.

Siliang Chen, M.D., and Jiarui Li, M.D., both from Peking Union Medical College Hospital in Beijing, investigated the representation status of Black U.S. residents in crucial clinical trials supporting U.S. Food and Drug Administration approval (2006 through 2020) of cardiovascular drugs (for hypertension, coronary artery disease, acute coronary syndrome or myocardial infarction, heart failure, atrial fibrillation, pulmonary arterial hypertension, and hypercholesterolemia).

The researchers found that the FDA approved 24 new molecular entity drugs for seven cardiovascular conditions during the study period. There were 187,294 participants enrolled in related clinical trials, including 5,396 Black participants and 155,694 White participants. Black participants represented 2.9 percent of total clinical trial participation (participation to prevalence ratio [PPR], 0.29), ranging from a PPR of 0.52 for Black participants in hypertension drug trials to a PPR of 0.72 in hypercholesterolemia trials. All PPRs were <0.8, indicating underrepresentation compared with total PPR of 1.14 among White participants, indicating overrepresentation.

“This marked underrepresentation might undermine the generalizability of use of new cardiovascular disease drugs in Black U.S. residents,” the authors write.

Abstract/Full Text

You May Also Like::  Provider Teams Outperform Solo Care for New-Onset Chronic Disease

“Keeping up with the indications and adverse reactions to immune checkpoint inhibitors can be a full-time job. Cutaneous side effects occur in up to 45% of patients treated with ipilimumab and 34% of patients treated with nivolumab and pembrolizumab.” https://bit.ly/3FGtxtd

.@spfnomt: This month’s #DermWorld article “Estate planning 101” is especially important for young physicians to read. The long, all-consuming years between adolescence and physicianhood can become a blur...https://bit.ly/3FxOtCv

That’s a wrap #AAD2023! 5 days of soaking up knowledge from dermatologists on topics such as hidradenitis, melasma, & dietary triggers of common dermatoses.

I LOVED the #womenshealth focused sessions on vulvar dermatoses and pregnancy medication safety.


New approach uses microbiome to treat skin disease by repairing the injured microbiome that allowed inflammation to flare up in the first place, rather than reducing the inflammation after the fact. https://bit.ly/3Jt6H9v

Load More