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Although FDG-PET imaging is the gold standard for interim response assessment in patients with classic Hodgkin lymphoma, this technique cannot be performed frequently. This study, published in the Journal of Extracellular Vesicles, examined a minimally invasive way to assess tumor presence and burden using microRNA (miRNA) associated with tumor-secreted extracellular vesicles (EV).

The study included 193 samples from 31 patients with classic Hodgkin lymphoma. Of these samples, 32 were used for small RNA sequencing and qRT-PCR. Ultimately, the researchers found that the level of tumor-associated miRNAs in plasma EVs was predictive of metabolic tumor activity in patients with classic Hodgkin lymphoma. 

The researchers concluded that plasma EV-miRNA is useful in detecting small residual lesions and may be applied to monitor treatment response in patients with classic Hodgkin lymphoma [1].


[1] Drees, E. E. E., Roemer, M. G. M., Groenewegen, N. J., Perez‐Boza, J., Eijndhoven, M. A. J., Prins, L. I., Verkuijlen, S. A. W. M., Tran, X., Driessen, J., Zwezerijnen, G. J. C., Stathi, P., Mol, K., Karregat, J. J. J. P., Kalantidou, A., Vallés‐Martí, A., Molenaar, T. J., Aparicio‐Puerta, E., Dijk, E., Ylstra, B., . . . Pegtel, D. M. (2021). Extracellular vesicle miRNA predict FDG‐PET status in patients with classical Hodgkin lymphoma. Journal of Extracellular Vesicles, 10(9). https://doi.org/10.1002/jev2.12121

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