October 24, 2021

Anti-VEGF intravitreal injections for wet age-related macular degeneration (AMD) are effective but burdensome for patients. This study, published in Investigative Ophthalmology & Visual Science, sought to evaluate the use of three non-invasive VEGFR tyrosine kinase inhibitors (TKIs) in treating choroidal neovascularization in mice.  The researchers studied three TKIs, sunitinib, pazopanib, and axitinib, in mice with laser-induced choroidal...

Hyperreflective foci indicate progression risk in cases of advanced age-related macular degeneration (AMD) and are partially attributable to ectopic retinal pigment epithelium (RPE). In this study, published in Investigative Ophthalmology & Visual Science, the authors hypothesized that ectopic RPE is molecularly distinct from in-layer RPE cells and has a cross-retinal course that follows Müller glia.  The...