Hidradenitis Suppurativa

M1 polarization of macrophages and their dynamic crosstalk with other cells, such as fibroblasts and lymphocytes, may explain the pathogenesis of hidradenitis suppurativa, providing new therapeutic strategies. Hidradenitis suppurativa (HS) is a chronic inflammatory dermatological condition involving the perianal, axillary, inguinal, and gluteal areas of the body. The disease pathogenesis is based on the dysregulation...

A systematic review reports that the drug survival of biologics in hidradenitis suppurativa is comparatively shorter than that of biologics for other dermatological conditions. Drug survival is a measure of the tolerability and efficacy of different treatment regimens. It is described by the proportion of patients who remain on the given treatment regimen over a...

Patients with hidradenitis suppurativa were found to have a significantly increased risk of periodontitis compared to both healthy controls and psoriasis patients in a retrospective cohort study. Hidradenitis suppurativa (HS) is characterized by chronic inflammation of the skin, accompanied by systemic symptoms. HS is associated with comorbid conditions in other organ systems. Periodontitis is an...

Clindamycin–benzoyl peroxide gel demonstrated comparable clinical efficacy to clindamycin lotion for the treatment of mild to moderate hidradenitis suppurativa in a pilot trial. Hidradenitis suppurative (HS) is defined as a chronic inflammatory cutaneous condition that involves inflammatory nodules, abscesses, tunnels, and scarring. Monotherapy with topical clindamycin is indicated for treating HS of mild-to-moderate severity. While...

The inhibition of heat shock protein 90 mediated by RGRN-305 serves as a potential therapeutic tool in the treatment of hidradenitis suppurativa, according to the results of a new clinical trial. Hidradenitis suppurativa (HS) is an immune-mediated systemic inflammatory condition, predominantly associated with cutaneous changes. Heat shock protein 90 (HSP90) mediates the activity of proinflammatory...

Compared to standard care, ambulatory care services are more cost-effective and are associated with decreased financial burden in the long term, according to the results of a randomized controlled trial.   Hidradenitis suppurativa (HS) is described as a chronic inflammatory cutaneous disorder and is associated with substantial treatment costs. The financial implications of the disease correlate...

Optical coherence tomography angiography demonstrates characteristic retinal vasculature features in patients with hidradenitis suppurative, allowing non-invasive monitoring of visual changes in this population. Hidradenitis suppurativa (HS) is associated with the relapsing–remitting course of suppuration and scarring. This disease has widespread systemic manifestations, including ocular complications, which prompt ocular examination in HS patients.  Optic coherence tomography...

In a phase I trial, interleukin-1 receptor-associated kinase 4 degrader was found to have robust clinical activity and a favorable safety profile in hidradenitis suppurativa and atopic dermatitis patients. Inflammation driven by toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs) is involved in the pathophysiology of hidradenitis suppurativa (HS) and atopic dermatitis (AD). IL-1R-associated kinase 4...

Hidradenitis suppurativa leads to a substantial decrease in work ability and productivity, according to the results of a prospective study. Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with lesions in intertriginous areas and areas with apocrine glands. Retrospective studies have described the disease burden as chronic and debilitating. A prospective, multicenter, epidemiological, noninterventional...