Crohn’s Disease

Medically reviewed by Dr. Shani S. Saks, D.O. on August 2, 2023 African-American Women have significantly higher pregnancy complication rates than White women. Maternal mortality rates among AAW are three times higher than for White women due to poor healthcare access, structural and medical racism, and resultant stresses. The presence of inflammatory bowel disease in...

Medically reviewed by Dr. Shani S. Saks, D.O. on August 23, 2023 A recent literature review suggests a significant difference in care delivery and, thus, treatment outcomes between rural and urban patients with inflammatory bowel disease. This difference is mainly attributed to poor access to gastroenterologists. However, there are ways to counter these disparities. Inflammatory...

Medically reviewed by Dr. Shani S. Saks, D.O. on August 23, 2023 In this study of perianal fistulizing Crohn’s disease patients and controls, the cellular composition of subcutaneous lipoaspirate was comparable; however, the platelet-rich plasma products in Crohn’s disease patients exhibited a greater number of myeloid cells of the regular phenotype. The combination of autologous...

Medically reviewed by Dr. Shani S. Saks, D.O. on August 2, 2023 Anti-tumor necrosis factor therapy and surgical treatment are recommended for recurrent fistulas in the absence of luminal inflammation. Perianal fistula is characterized by pathological connections between the perianal skin and the anorectal canal. The majority are cryptoglandular fistulas that develop from infected anal...

Medically reviewed by Dr. Shani S. Saks, D.O. on August 2, 2023 Darvadstrocel was found to be safe and effective for Crohn’s disease patients suffering from treatment-refractory complex perianal fistulas. Darvadstrocel is a suspension of allogeneic adipose-derived mesenchymal stem cells (eASCs). Darvadstrocel is safe and effective in Crohn’s disease (CD) patients suffering from treatment-refractory complex...

Medically reviewed by Dr. Shani S. Saks, D.O. on August 23, 2023 The genetic coding variant rs4151651, in complement factor B, altered complement factor cleavage, alternative pathway activation, and phagocytosis of the pathogen in subjects with perianal Crohn’s disease. Perianal Crohn’s disease (pCD) is a prevalent condition in CD patients that is related to uncertain...

Medically reviewed by Dr. Shani S. Saks, D.O. on August 23, 2023 Anti-tumor necrosis factor (TNF) therapy with surgical closure was positively associated with radiological healing and improved incontinence in patients with Crohn’s perianal fistulas. The results of this study indicate that surgical closure may be considered in patients responsive to anti-TNF treatment, which can...

Prevalence was higher in White than Black, Asian, and Hispanic American populations The incidence of inflammatory bowel disease (IBD) is 10.9 per 100,000 person-years and prevalence is 721 per 100,000 population, according to a study published online July 20 in Gastroenterology. James D. Lewis, M.D., from the University of Pennsylvania in Philadelphia, and colleagues estimated the...

No difference seen in 28-day mortality or occurrence of serious adverse events; time to resolution of ACLF significantly faster. The DIALIVE novel liver dialysis device seems safe and has a positive impact for patients with acute-on-chronic liver failure (ACLF), according to a study published online May 31 in the Journal of Hepatology. Banwari Agarwal, M.B.B.S.,...