December 24, 2021

Tumor mutational burden (TMB) can function as a biomarker for response to immunotherapy. Understanding how to accurately test TMB and understanding the implications of variation in the results can inform treatment. This study, published in Clinical Research (Excluding Clinical Trials), analyzed the genomic profiles of patients with cancer to assess TMB prevalence and variability, and its...

The PD-L1 IHC 22C3 pharmDx is an FDA-approved companion diagnostic to pembrolizumab designed for use on Autostainer Link 48. This study, published in Pathology, compared a 22C3 antibody-based laboratory-developed test (LDT) on BenchMark XT with the FDA-approved PD-L1 IHC 22C3 pharmDx. Pan-tumor data for this study included samples from a total of 327 patients with esophageal...