June 27, 2023

This study provides a review of the interaction between cancer and kidney disease to develop nephroprotective strategies during chemotherapy. The inter-relationship between cancer and kidney disease emphasizes the importance of onco-nephrology. Chemotherapeutic agents can affect renal function and result in acute kidney injury (AKI) or chronic kidney disease (CKD) in cancer survivors. Moreover, the co-existence...

This study reviewed the role of extracellular vesicles in renal cell carcinoma progression and their potential future clinical applications. Extracellular vesicles (EVs) are nanosized vesicles released into the extracellular spaces by most cell types, including cancer and non-cancer cells. EVs secreted by renal cell carcinoma (RCC) play a role in various steps of cancer progression....

This article elucidates the metabolic pathways of rapamycin and its derivatives, intending to propose a strategy for implementing personalized medicine. Rapamycin (sirolimus) and its derivatives are immunosuppressants and chemotherapeutic agents used in cancer treatment. As the paradigm shifts towards personalized medicine, it is essential to identify the factors impacting the effectiveness of these drugs. A...

Fascin-1 has a promising role as a biomarker in urologic cancers. Metastasis is the leading cause of poor prognosis in urologic cancers. Early diagnosis and effective treatments for metastatic cancer would improve the survival rate. Fascin-1 is an actin-binding protein involved in cell division, migration, and intercellular interactions. There is frequent upregulation of fascin-1 in...

This experimental study of the tear fluid proteome demonstrated that the proteins found in the tear fluid of multiple sclerosis patients are modified and may indicate inflammation, which can be helpful in the diagnosis and treatment of these patients. Multiple sclerosis (MS) is a neurodegenerative condition that involves the central nervous system (CNS). The diagnostic...

Utilizing an eye-tracking system for bed positioning based on eye movements is a viable and dependable option for individuals experiencing advanced stages of multiple sclerosis.  Individuals with advanced multiple sclerosis (MS) who exhibit limited motor abilities must have frequent position changes to prevent further complications. A newly published study describes the development and utility of...

Apigenin exerts its inflammatory properties by mediating the inhibition of the proliferation of interferon gamma-secreting Th1 cells. The acetylated version of apigenin-3-acetate exhibits comparative immunomodulatory outcomes compared to methyl-prednisolone-acetate and apigenin. Despite advancements in the treatment modalities for multiple sclerosis (MS), the associated morbidity remains high. A study published in Cell Journal evaluated the immunomodulatory...

Utilizing interventions to treat mental health impairments in patients suffering from immune-mediated inflammatory diseases, such as irritable bowel disease, multiple sclerosis, and rheumatoid arthritis, can aid in improving mental health. Mental illnesses are prevalent among individuals suffering from immune-mediated inflammatory diseases (IMID), such as multiple sclerosis (MS), inflammatory bowel disease (IBD), and rheumatoid arthritis (RA);...

A single disease relapse in neuromyelitis optica spectrum disorder is associated with a worsening of disability and health-related quality of life outcomes; therefore, implementing relapse prevention measures is crucial to improving long-term outcomes. Multiple relapses in patients suffering from neuromyelitis optica spectrum disorder (NMOSD) render them susceptible to long-term disability and poor health-related quality of...