August 4, 2023

Medically reviewed by Dr. Shani S. Saks, D.O. on August 23, 2023 In this study of perianal fistulizing Crohn’s disease patients and controls, the cellular composition of subcutaneous lipoaspirate was comparable; however, the platelet-rich plasma products in Crohn’s disease patients exhibited a greater number of myeloid cells of the regular phenotype. The combination of autologous...

Medically reviewed by Dr. Shani S. Saks, D.O. on August 2, 2023 Anti-tumor necrosis factor therapy and surgical treatment are recommended for recurrent fistulas in the absence of luminal inflammation. Perianal fistula is characterized by pathological connections between the perianal skin and the anorectal canal. The majority are cryptoglandular fistulas that develop from infected anal...

Medically reviewed by Dr. Shani S. Saks, D.O. on August 2, 2023 Darvadstrocel was found to be safe and effective for Crohn’s disease patients suffering from treatment-refractory complex perianal fistulas. Darvadstrocel is a suspension of allogeneic adipose-derived mesenchymal stem cells (eASCs). Darvadstrocel is safe and effective in Crohn’s disease (CD) patients suffering from treatment-refractory complex...

Medically reviewed by Dr. Shani S. Saks, D.O. on August 23, 2023 The genetic coding variant rs4151651, in complement factor B, altered complement factor cleavage, alternative pathway activation, and phagocytosis of the pathogen in subjects with perianal Crohn’s disease. Perianal Crohn’s disease (pCD) is a prevalent condition in CD patients that is related to uncertain...

Medically reviewed by Dr. Shani S. Saks, D.O. on August 23, 2023 Anti-tumor necrosis factor (TNF) therapy with surgical closure was positively associated with radiological healing and improved incontinence in patients with Crohn’s perianal fistulas. The results of this study indicate that surgical closure may be considered in patients responsive to anti-TNF treatment, which can...

Medically reviewed by Dr. Shani S. Saks, D.O. on August 2, 2023 The short-term family-focused intervention had a non-significant positive effect on health-related quality of life and improved perceived family support, anxiety, and depression in patients and family members.

Medically reviewed by Dr. Shani S. Saks, D.O. on August 2, 2023 A mobile health technology intervention consistently reduced primary composite outcomes comprising all-cause death, systemic embolism, rehospitalization, and ischemic stroke for primary and secondary prevention. The risk of thromboembolic recurrences is higher in atrial fibrillation (AF) patients with a previous history of thromboembolic events,...

Medically reviewed by Dr. Shani S. Saks, D.O. on August 2, 2023 Lower access rates to catheter ablation therapy were related to low socioeconomic background, female gender, and racial minorities, in this study. Atrial fibrillation (AF) is considered one of the most common cardiac arrhythmias worldwide, and its occurrence and prevalence are expected to increase...

Medically reviewed by Dr. Shani S. Saks, D.O. on August 2, 2023 Intracardiac echocardiography-guided zero-fluoroscopic cryoballoon ablation was found to be a feasible approach in atrial fibrillation patients and was without any significant effects related to complications or success rates of the procedure. Zero-fluoroscopic cryoballoon ablation (CBA) is a challenging intervention owing to the absence...