September 8, 2023

Medically reviewed by Dr. Kimberly Langdon Cull, M.D. on Oct. 4, 2023 A recent study found that inner retinal layer atrophy, assessed using optical coherence tomography, was associated with worsening ambulation in patients with primary progressive multiple sclerosis. This indicates that optical coherence tomography can be utilized for monitoring disability progression in multiple sclerosis patients. Disability...

Medically reviewed by Dr. Kimberly Langdon Cull, M.D. on Oct. 4, 2023 This meta-analysis demonstrated that the majority of individuals taking paroxetine experienced a reduction in vasomotor symptoms (hot flashes); however, the same effect could be achieved by an inert placebo. The maximum true effect of paroxetine is estimated to be 32%. Vasomotor symptoms, including hot...

Medically reviewed by Dr. Kimberly Langdon Cull, M.D. on Oct. 4, 2023 Peripheral reactive B cells have a dual role in the pathogenesis and diagnosis of multiple sclerosis. These cells deliver myelin autoreactive antibodies to oligodendrocytes, which can also be a diagnostic biomarker in multiple sclerosis. Multiple sclerosis (MS) is characterized by a pathogenic immune response...

Preliminary evidence shows that obesity may lead to renal inflammation and an unbalanced renal tissue lipidic profile, particularly after menopause. Obesity is a risk factor for chronic kidney disease (CKD). However, the prevalence of CKD has not increased in parallel with the obesity pandemic. It is important to identify the patients in whom obesity induces...

The findings of a preliminary investigation indicate that Nitraria retusa tea may be safe and effective for reducing serum cholesterol levels. Medications for reducing the risk of dyslipidemia have various side effects, highlighting the need for safer alternatives for prevention and treatment. One study showed that the Nitraria retusa plant inhibited cell differentiation in 3T3-L1...

This study found a negative association between asthma in children and the intake of docosahexaenoic acid in the diet, particularly in male children between 5 and 12 years of age with a history of maternal smoking during the gestation period.  The development of childhood asthma involves behavioral, genetic, and environmental changes. Polyunsaturated fatty acids (PUFA)...

Systemic inflammation and vascular function were not affected by immediate airway challenges involving bronchoconstriction (methacholine) or inflammation and bronchoconstriction (mannitol) in a recent clinical trial. Asthma is a persistent respiratory disorder characterized by repetitive instances of inflammation in the airways, leading to the constriction of the bronchial tubes and the manifestation of symptoms such as...

The administration of dupilumab is associated with an increased risk of the development of eosinophilic granulomatosis with polyangiitis in asthma patients with higher peripheral blood eosinophil counts. Dupilumab is a monoclonal antibody that acts against interleukin-4 receptor α (IL-4Rα), suppressing type 2 inflammation. Patients undergoing treatment with dupilumab may develop eosinophilia, characterized by a peripheral...

This study demonstrated the long-term efficacy of mepolizumab, a monoclonal interleukin-5 antibody, in reducing asthma exacerbations, steroid dependence, and nasal polyps over a 3-year period. Mepolizumab (MEP) is a monoclonal antibody that acts against interleukin (IL)-5 to control the proliferation, maturation, and activity of eosinophils. The efficacy of MEP in patients with severe asthma has...