November 30, 2023

This study found that the neck disability index is higher in patients with neuropathic pain. A positive correlation was observed between neuropathic pain screening score and functional deterioration of study participants with cervical radicular pain. Cervical radicular pain is frequently caused by herniation of a disc or degenerative spondylosis. This type of pain is perceived...

Novel osmoscan-derived biomarkers Omin-width and Omax-width exhibited correlations with RDW, hyperchromic cells (Omax-width), OFT outcomes (Omin-width), and clinical severity in a monocenter retrospective cohort study. Hereditary spherocytosis (HS) is characterized by membrane instability of red blood cells (RBCs) and resultant instability and loss of the cell membrane due to pathogenic variants in genes involved in...

In adult patients with primary autoimmune hemolytic anemia (AIHA) undergoing rituximab treatment, there was a notable prevalence of hospitalizations due to infections, with a subsequent high mortality rate post-hospitalization, according to the results of a prospective study. The development of auto-antibodies against the red blood cells underlies the pathology of autoimmune hemolytic anemia (AIHA), which...

Sutimlimab is generally well tolerated, and the frequency and nature of treatment-emergent adverse events are consistent with those observed in elderly, medically complex patients, according to an analysis of data from two phase 3 studies. Cold agglutinin disease (CAD) is characterized by autoimmune hemolytic anemia mediated by the classical complement pathway. Sutimlimab, a monoclonal humanized...

The administration of zinc supplements proved to be effective in treating anemia, resulting in full recovery in 35% and a progressive increase in hemoglobin concentrations over the course of one year in chronic kidney disease patients with zinc deficiency and anemia, as reported in a retrospective study. Anemia in chronic kidney disease (CKD) is associated...

This preliminary study revealed that mice with certain genetic variants exhibit anemia, emphasizing the importance of LDHA in red blood cell erythropoiesis. Glycolysis, or the metabolism of glucose, is integral to cellular life. The pyruvate obtained in glycolysis is either converted to lactate or oxidized into the tricarboxylic acid cycle. The former process is catalyzed...

This study will investigate the use of bitopertin, an oral GlyT1 glycine transporter inhibitor, in treating steroid-refractory Diamond–Blackfan anemia, which is characterized by bone marrow failure and often exhibits poor response to systemic corticosteroids. Bitopertin aims to rebalance hemoglobin synthesis by slowing heme production.  Diamond–Blackfan anemia (DBA) is described as a bone marrow failure disorder....