December 2, 2023
Erythrophagocytosis Mediated By Circulating Monocytes Is Induced By Distinct Mechanisms
In sickle cell anemia, red blood cells have a predominant role in the enhancement of phagocytic activity by mast cells, but in polycythemia vera, both cell types contribute to this phenomenon Stress erythropoiesis (SE) occurs when the physiological process of erythropoiesis is insufficient to fulfill the required production of functional red blood cells (RBCs), resulting...
PIEZO1's Effects on Stressed Erythropoiesis, Dyserythropoiesis, and Dehydrated Hereditary Stomatocytosis
Gain-of-function mutations in the PIEZO1 mechanosensor channel affect intracellular calcium concentration, affecting late-stage differentiation and disrupting apoptosis, hypoxia response, and glycolysis, according to a new study. PIEZO1 is an important mechanosensitive cation channel that detects mechanical forces and is involved in many physiological functions. Its function in erythrocytes is to control hydration and cellular volume....
Iron Deficiency Anemia Effects on Cerebrovascular Physiology in Healthy Women
Iron deficiency impairs cognition, and a recent study found that those with hemoglobin < 10.0 g/dl scored more than one standard deviation below those with milder anemia. A hemoglobin level below 11 g/dl, considered moderate iron deficiency anemia (IDA), affects 1.5 percent of the U.S. population and is more common among minority groups. However, little...
Dr. Maggie Cadet: Managing Rheumatoid Arthritis
In this MD Newsline exclusive interview with rheumatologist Dr. Maggie Cadet, we discuss Dr. Cadet’s treatment strategy for rheumatoid arthritis. We also discuss the importance of helping patients understand and prevent the complications of rheumatoid arthritis. MD Newsline: What is your treatment strategy for rheumatoid arthritis, and how is it tailored to each patient? How...
Dr. Maggie Cadet: Rheumatoid Arthritis Disparities
In this MD Newsline exclusive interview with rheumatologist Dr. Maggie Cadet, we discuss the disparities experienced by minority populations with rheumatoid arthritis. We also discuss the role of socioeconomic status and education in arthritis management and how to rectify rheumatoid arthritis disparities. MD Newsline: Why do African Americans, Hispanic Americans, and American Indians/Alaska Natives experience...
Dr. Maggie Cadet: Rheumatoid Arthritis and the Pandemic
In this MD Newsline exclusive interview with rheumatologist Dr. Maggie Cadet, we discuss rheumatoid arthritis management challenges and disparities during the COVID-19 pandemic. MD Newsline: What are the biggest challenges that rheumatologists are tasked with in the wake of COVID-19? Dr. Maggie Cadet: “It has been challenging to assuage our patients’ fears of getting vaccinated for COVID-19....