March 1, 2024

A phase III study suggests that olaparib-bevacizumab is not only effective for high-risk (of relapse) HRD-positive tumors but is even more effective for low-risk patients in prolonging progression-free survival. Cure is the ultimate goal of ovarian cancer treatment; however, ovarian cancer patients are often first diagnosed at advanced stages, with an increased risk of relapse....

The phase 2 DAISY trial confirms that T-DXd efficacy depends on HER2 expression in breast cancer cases. However, it shows that T-DXd also has moderate activity in HER2-non-expressing patients, suggesting an alternative mechanism of action. Breast cancer is among the five most common causes of cancer mortality. Despite improvements in its treatment, 5-year survival rates...

Health-tracking apps are useful for shared decision-making, according to a recent study that showed that eczema patients were willing to use disease progress and treatment tracking apps, providing valuable information to clinicians. Using mobile apps can contribute to disease management and may particularly be useful for improving shared decision-making (SDM), which can improve patient outcomes...

Treatment with bimekizumab for patients with moderate-to-severe plaque psoriasis showed significant positive results and clinical outcomes in a phase 3 study. Plaque psoriasis is a chronic inflammatory illness mediated by the immune system. It causes large skin lesions that can be scaly, thick, and, at times, pruritic. This substantial illness burden influences patients’ quality of...

A sub-analysis of a multicountry study reports that, in addition to physical symptoms like pain and itching, individuals with AD also suffer from a decreased quality of life, which is evident through disrupted sleep, decreased ability to work, financial burdens, heightened anxiety/depression, and limited capacity to perform everyday tasks. Atopic dermatitis (AD) is a persistent,...

Dupilumab effectively manages atopic dermatitis by reducing clinical scores and improving itchiness, sleep quality, disease control, and overall quality of life, according to the results of a single-center retrospective study. Atopic dermatitis (AD) is a chronic, inflammatory skin condition characterized by severe itching and recurrent eczematous skin lesions. AD is associated with symptoms such as...

Children and adolescents with atopic dermatitis are more inclined to exhibit aggressive behavior, which not only presents physical difficulties but additionally has a negative effect on their psychological well-being, according to the findings of a new cross-sectional study. Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by recurrent eczematous lesions and itching. Although...

Long-term treatment with remibrutinib shows favorable safety and tolerability and demonstrated robust clinical efficacy in patients with chronic spontaneous urticaria, according to the results of a phase 2b trial. Chronic spontaneous urticaria (CSU) is a condition in which wheals (hives) and/or angioedema occur persistently for longer than 6 weeks, greatly affecting the quality of life...

Interleukin-9 and apolipoprotein A-IV could serve as new biomarkers for predicting the severity of urticaria, according to the results of a recent observational study. Chronic spontaneous urticaria (CSU) is a condition characterized by the presence of wheals, with or without angioedema, that occur daily or almost daily for more than 6 weeks. Previous studies have...