Clinical manifestations of sickle cell disease, such as hemolytic anemia, pain, and progressive organ damage, can be alleviated by high levels of erythrocyte fetal hemoglobin (HbF). The BCL11A gene represses γ-globin expression and adult erythrocyte fetal hemoglobin production. This study, published in the New England Journal of Medicine, focuses on the genetic silencing of BCL11A, resulting...