Neurology

Depression, anxiety, and sleep disturbances are highly prevalent in neuromyelitis optica spectrum disorder patients, according to a recent study. Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease primarily affecting the visual pathway, brain, and spinal cord. Global NMOSD incidence rates are 0.039–0.73/100,000 person-years in adults and 0.01–0.06/100,000 person-years in children. Psychiatric issues like...

A recent study provides a topical review of double-negative neuromyelitis optica spectrum disorder. Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease with a predisposition for the optic nerves and spinal cord. Most NMOSD patients are seropositive for aquaporin-4-antibody (AQP4-IgG) or myelin oligodendrocyte glycoprotein antibodies (MOG-IgG); those who are negative for both are termed double-negative...

Serum neurofilament light chain level shows promise as a biomarker for predicting spinal cord atrophy in neuromyelitis optica spectrum disorder. Serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP) levels are linked to disease activity and disability in patients with neuromyelitis optica spectrum disorder (NMOSD). High sNfL levels are associated with brain...

Utilizing social networks can improve efficacy and safety outcomes in low-dose rituximab therapy for central nervous system demyelinating diseases, according to a recent study. The impact of social media extends into the domains of healthcare and medical research. The complex nature of central nervous system (CNS) demyelinating diseases requires ongoing research, careful treatment monitoring, and...

A recent study found that frontoparietal and peri-ependymal white matter disconnection is associated with disability in neuromyelitis optica spectrum disorder patients. Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system. Evidence suggests a distinct pattern of brain lesions in NMOSD, and it may be related to disability.  A study in...

A recent study concludes that cerebrospinal fluid/serum albumin quotient and platelet-to-lymphocyte ratio can effectively serve as independent disease severity markers for neuromyelitis optica spectrum disorder. Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease that primarily affects the optic nerves and the spinal cord. The disease often leads to severe disability over time.  A...

A recent retrospective study provides an overview of the clinical and demographic characteristics of neuromyelitis optica spectrum disorder patients in Slovakia. Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune, inflammatory disease of the central nervous system, predominantly affecting the optic nerves and the spinal cord. It has two distinct phenotypes based on the presence of...

Disease reactivation is likely to occur after stopping eculizumab in neuromyelitis optica spectrum disorder with a long-term stable course, according to a recent study. Neuromyelitis optica spectrum disorder (NMOSD) is a neuroinflammatory disease primarily affecting the optic nerves and spinal cord. Eculizumab, a humanized monoclonal antibody, is effectively used for the treatment of aquaporin-4-IgG seropositive...

Anti-CD20 therapies increase while mRNA vaccines decrease the risk of COVID-19 in multiple sclerosis and neuromyelitis optica patients. During the COVID-19 pandemic, concerns were raised for vulnerable patients suffering from neuroinflammatory diseases, such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). MS patients showed a higher hospitalization rate with COVID-19 than the general...