A screening of the differentially expressed genes based on the Gene Expression Omnibus database and further gene enrichment analysis indicates that the tyrosine kinase-binding protein TYROBP is a potential prognostic marker for multiple myeloma.
Multiple myeloma is a refractory hematological cancer characterized by the malignant proliferation of plasma cells. The tyrosine kinase-binding protein TYROBP mediates the inflammatory response of the body and can serve as a potential prognostic marker and therapeutic target for different cancers.
In this study, the authors screened differentially expressed genes (DEGs) associated with multiple myeloma based on the Gene Expression Omnibus (GEO) database. The findings are published in the journal Cancer Cell International.
Survival Analyses and Diagnostic Significance of Hub Genes
Differential analysis of hub genes in the GSE39754 and GSE6477 datasets between healthy donors and multiple myeloma patients was performed and verified. Only the MNDA, ELANE, MPO, and TYROBP hub genes demonstrated significant expression in the high-expression groups compared to the low-expression groups.
Prognostic Significance of Hub Genes in Gene Enrichment Analysis
The Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of high- and low-TYROBP-expression groups indicated significant changes in the tuberculosis signaling pathways, cell adhesion, chemokine pathways, neutrophil peripheral trap formation, and phagocytic vesicles.
Prognostic Significance of TYROBP for Different Clinical Characteristics
The Kaplan–Meier (KM) analysis of the high- and low-TYROBP-expression groups indicated that TYROBP had prognostic significance for female patients aged < 65 years, with MRI lesions and IGA type.
Downregulation and Upregulation of TYROBP in Multiple Myeloma
Compared to the healthy donors, TYROBP protein expression was significantly decreased in multiple myeloma patients. By contrast, when TYROBP was up-regulated in multiple myeloma cells, cell adhesion was promoted and the ability of the myeloma cells to migrate was reduced.
Source:
Hong, L., Pan, C., Wang, L., Zheng, L., Cao, S., Hu, X., Hu, T., Zhao, N., Shang, Q., & Wang, J. (2024). Low TYROBP expression predicts poor prognosis in multiple myeloma. Cancer Cell International, 24(1). https://doi.org/10.1186/s12935-024-03304-6
