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Maintenance darunavir/ritonavir monotherapy was effective in the prevention of perinatal HIV transmission in a recent study; however, about 10% of the cases required treatment intensification. Nucleoside reverse transcriptase inhibitors (NRTIs) are associated with drug-related toxicities in both fetal and neonatal stages. However, despite known toxicities, NRTIs are recommended for neonatal prophylaxis against HIV during pregnancy. ...

Microarray patches were found to be acceptable as both multipurpose prevention technology and pre-exposure prophylaxis among participants of a recent study; however, some participants expressed a preference for multipurpose prevention technology. Microarray patches (MAPs) are being developed as a multipurpose prevention technology (MPT) in order to prevent unplanned pregnancies and human immunodeficiency virus (HIV) infection....

In a phase I trial, interleukin-1 receptor-associated kinase 4 degrader was found to have robust clinical activity and a favorable safety profile in hidradenitis suppurativa and atopic dermatitis patients. Inflammation driven by toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs) is involved in the pathophysiology of hidradenitis suppurativa (HS) and atopic dermatitis (AD). IL-1R-associated kinase 4...

STIs and HIV tend to affect marginalized communities that can be harder to access. This study describes some features of community-based peer navigation, which can help reach these communities more effectively.  Sexually transmitted infections and HIV, in particular, affect young gay, bisexual, and other men who have sex with men GBMSM, along with transgender women...

Although treatments for HIV have dramatically improved, disparities persist along racial lines. These are amplified when considering potential life lost. Since the introduction of antiretroviral therapies, the mortality rates of people with HIV have decreased substantially. However,  premature deaths are currently not included in these calculations. Additionally, sex and race disparities persist. Various minority groups...

Lipid mediators of inflammation exhibit altered profiles in HIV, along with an impaired response to aspirin. People with HIV (PWH) are at a higher risk of cardiovascular disease than the general population. Inflammation is an important contributor to this increased risk. Despite this, lipid inflammatory mediators and their response to aspirin have not been comprehensively...

Improvement in bone quality is observed after switching from the tenofovir disoproxil fumarate regimen to the tenofovir alafenamide regimen of antiretroviral therapy. People living with HIV (PLWH) are at a higher risk of bone fractures than the general population. As longevity improves with antiretroviral therapy (ART), fracture rates are also predicted to increase in this...

A South African study reveals that among individuals of lower socioeconomic status, men are less likely than women to seek HIV testing, while women from similar backgrounds who engage in risky sexual behavior are at greater risk of HIV infection. South Africa has one of the highest HIV rates in the world, affecting about 19.1%...

Sulfated endospermic nanocellulose crystals were shown to have antiviral activity by irreversibly interacting with viral particles via cross-linking, thereby inhibiting viral infections. Sulfated endospermic nanocellulose (ENC) crystals are biomaterials that have antimicrobial activity. ENC can be derived from the parenchyma of ivory nut endosperm and used against microbes after its binding capacity is enhanced by...

Persons with HIV (PWH) hospitalized with COVID-19 have similar outcomes to demographically-matched patients without HIV, according to a study published online June 28 in Clinical Infectious Diseases. Keith Sigel, M.D., Ph.D., from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues compared outcomes for PWH and COVID-19 with a matched comparison...