A randomized controlled trial reports that Ziziphus jujube syrup was an effective add-on treatment for a group of patients with chronic spontaneous urticaria resistant to standard second-generation H1 antihistamines.
Chronic spontaneous urticaria (CSU) is an intermittent condition characterized by urticaria and/or angioedema lasting for a minimum of 6 weeks. The first-line management of CSU includes second-generation H1 antihistamines; however, the standard dosage regimen yields poor clinical response.
This double-blind randomized controlled trial, published in the Iranian Journal of Medical Sciences, investigated the effectiveness of added-on Ziziphus jujube syrup in standard dosage second-generation H1 antihistamine in CSU patients.
Participant Characteristics
The study included a total of 64 patients, who were equally randomized into intervention and control groups. The intervention and control groups included five and ten males, respectively. The mean age in the control group was 36.66 ± 13.53 years, and the mean age of intervention group participants was 37.88 ± 9.36 years. There were no statistically significant differences between the baseline variables of either group.
Urticaria Activity Score
Compared to the control group, the intervention group participants demonstrated a statistically significant change in urticaria activity score (UAS) on the 7th day.
Quality of Life
Both intervention and control groups demonstrated a statistically significant improvement in mean chronic urticaria quality of life (CU-Q2oL) values at 28 days. Patients with higher CU-Q2oL scores had worse conditions. Approximately 70% improvement was observed in the intervention and control groups.
Sleep Quality
The generalized estimating equation analysis demonstrated that herbal medications were associated with significant improvement in sleep quality in the control and intervention groups.
High-Performance Liquid Chromatography Findings
High-performance liquid chromatography findings indicated that the primary components of Ziziphus jujube syrup were hesperetin and gallic acid.
In summary, treatment with Ziziphus jujube syrup as an adjuvant to standard dose second-generation H1 antihistamine was effective for improving treatment outcomes in CSU patients in this study with no adverse effects reported.
Source:
Zare, H. R., Nabavizdeh, S. H., Jaladat, A. M., Zarshenas, M. M., Moghtaderi, M., Basirat, A., & Nasri, N. (2023). The Added-on of Ziziphus jujube Syrup in the Treatment of Chronic Spontaneous Urticaria Resistant to Standard-Dose of Secondary-generation H1 Antihistamine: A Double-Blind Randomized Clinical Trial. PubMed, 48(6), 582–590. https://doi.org/10.30476/ijms.2023.95531.2690
