December 10, 2020
Lack of Sleep Tied to Physician Burnout, Medical Errors
THURSDAY, Dec. 10, 2020 (HealthDay News) — Sleep-related impairment among physicians is associated with increased burnout, decreased professional fulfillment, and increased self-reported clinically significant medical error, according to a study published online Dec. 7 in JAMA Network Open. Mickey T. Trockel, M.D., Ph.D., from the Stanford University School of Medicine in Palo Alto, California, and...
ASH: CRISPR-Cas9 Gene Editing Promising in TDT, SCD
THURSDAY, Dec. 10, 2020 (HealthDay News) — Use of the ex vivo CRISPR-Cas9-based gene-editing platform to edit the erythroid enhancer region of BCL11A in hematopoietic stem and progenitor cells, producing CTX001, results in increased hemoglobin (Hb) among patients with transfusion-dependent ß-thalassemia (TDT) and sickle cell disease (SCD), according to a study published online Dec. 5...
Kidney Disease Leading Risk Factor for COVID-19 Hospitalization
THURSDAY, Dec. 10, 2020 (HealthDay News) — Kidney disorders are the strongest preexisting factor associated with COVID-19-related hospitalization, according to a study published online Nov. 12 in PLOS ONE. Matthew T. Oetjens, Ph.D., from the Geisinger Health System in Danville, Pennsylvania, and colleagues used electronic health record data to assess pre-COVID-19 pandemic clinical phenotypes (12,971...
Risk Factors for Severe COVID-19 Up in Cancer Survivors
THURSDAY, Dec. 10, 2020 (HealthDay News) — Cancer survivors are at higher risk for comorbidities that are considered risk factors for severe COVID-19 outcomes, according to a study published online Nov. 30 in EClinicalMedicine. Helena Carreira, Ph.D., from the London School of Hygiene and Tropical Medicine, and colleagues compared survivors (for at least one year)...
Obesity Duration Tied to Higher Cardiometabolic Disease Risk
THURSDAY, Dec. 10, 2020 (HealthDay News) — Longer obesity duration is associated with worse cardiometabolic disease risk factors, according to a study published online Dec. 8 in PLOS Medicine. Tom Norris, Ph.D., from Loughborough University in the United Kingdom, and colleagues used harmonized body mass index and cardiometabolic disease risk factor data from 20,746 participants...
Genetic Ancestry Tied to Lung Cancer Mutations in Latin Americans
THURSDAY, Dec. 10, 2020 (HealthDay News) — Lung cancer samples from individuals with native American ancestry have increased mutations in the EGFR gene, according to a study published online Dec. 2 in Cancer Discovery. Jian Carrot-Zhang, Ph.D., from the Dana-Farber Cancer Institute in Boston, and colleagues conducted genomic and ancestry analysis of 1,153 lung cancers...