October 13, 2022

A recent review article explored the effects of sleep behaviors and disorders on the progression of pre-diabetes to type 2 DM and found positive associations with insomnia, night shift duty, and short sleep duration. Certain sleep disorders, including short/long sleep duration (SD), insomnia, daytime napping, obstructive sleep apnea (OSA), and changes in the sleep–wake cycle,...

Earlier onset of type 2 DM compared to late-onset type 2 DM increases the risk of developing microvascular complications, but may not increase risk of macrovascular complications. Patients with EOD may benefit from preventive and therapeutic measures before the onset of symptoms of vascular complications. Microvascular and macrovascular complications of type 2 diabetes mellitus (DM)...

Empagliflozin is an SGLT-2i with positive treatment outcomes in patients with T2DM and HF, though it was not originally developed for the combination of these conditions. Future long-term and well-designed clinical trials are needed to support these findings. Type 2 diabetes mellitus (T2DM) and heart failure (HF) are the two of the most common medical...

GDM in ≥ 1 pregnancy is associated with a significant risk of developing type 2 DM in the affected women. The risk remains elevated for > 35 years, according to a recent study. Gestational diabetes mellitus (GDM) is characterized by the onset of hyperglycemia in the second or third trimester in pregnant women without a...

Type 2 diabetes mellitus (DM) and advanced glycation end product (AGE) pathophysiology affect the metabolism of proteins, carbohydrates, and lipids, which in turn mediate oxidative stress and inflammation in the background of chronic hyperglycemia. A newly published review provides an in-depth look at the vascular effects of AGEs in DM. Type 2 diabetes mellitus (DM)...

Advancements in genomics research have opened up new avenues of treatments for sickle cell disease. This article highlights some of the most promising innovative approaches. Sickle cell disease is a group of inherited blood disorders, the most commonly known of which is sickle cell anemia. The disease is caused by an amino acid substitution at...

Sickle cell disease is a complex and difficult condition to manage. A recent study has identified several socio-economic barriers that add to the clinical challenges of sickle cell disease, impeding timely and effective care and driving up healthcare costs. Introduction Sickle cell disease (SCD) is often associated with complications that lead to higher than normal...