February 5, 2024
Barzolvolimab Efficacy in Inducible Chronic Urticaria
An ongoing phase 1b study investigates the efficacy of barzolvolimab, a monoclonal antibody targeting the KIT receptor, for chronic inducible urticaria. Barzolvolimab was found to provide rapid relief, suppress mast cell activity, and significantly improve urticaria control and patients’ quality of life. Chronic inducible urticaria (CIndU) is a subset of chronic urticaria that includes conditions...
The Gut Microbiome Connection to Persistent Urticaria
Research indicates significant alterations in the gut microbiota of chronic spontaneous urticaria patients, characterized by reduced diversity, lower levels of SCFA-producing bacteria, and increased pathogenic bacteria. Chronic spontaneous urticaria (CSU) is the most common type of chronic urticaria (CU), often lasting for a few years despite intensive medical treatment. Moreover, relapse rates for the condition...
Managing Resistant Hives Effectively Without Monoclonal Antibodies
A recent randomized controlled trial shows that patients who do not respond to initial therapy with nonsedating H1-antihistamines might respond to these drugs when given at four-fold higher dosages. Urticaria is a common dermatological condition that can be acute or chronic. Chronic urticaria (CU) persists for more than 6 weeks and requires frequent healthcare visits,...
Exploring Treatment Advances in Chronic Spontaneous Urticaria Through Pathophysiology
Chronic spontaneous urticaria (CSU) presents treatment challenges, with 61% unresponsive to antihistamines. The findings of a recent literature review reveal the pivotal role of mast cells and identify two autoimmune responses as potential targets of new treatment approaches. Chronic spontaneous urticaria (CSU) is a common, poorly understood immunological disease. Skin infestations, like recurrent wheals and...
Association Between Apolipoprotein B/A1 Ratio and Optical Coherence Tomography Examination
The apolipoprotein B/A1 ratio can be used to predict the amount of tissue prolapse seen on an optical coherence tomography scan, and it is linked to how easily the apolipoprotein B/A1 plaque can break, according to a recent single-center, cross-sectional analysis. The apolipoprotein (Apo) B/A1 ratio is considered a reliable predictor of atherosclerotic cardiovascular disease....
Remnant Cholesterol and the Risk of Aortic Valve Calcium Progression
An analysis of cohort data from the Multi-Ethnic Study of Atherosclerosis database found that elevated remnant cholesterol is a residual risk factor for aortic valve calcium progression, regardless of the conventional cardiovascular risk factors. Aortic valve calcium (AVC) is associated with the development of calcific aortic valve disease, which is one of the leading causes...