ASH 2023

The influence of hydroxyurea on fertility is complex, and cryopreservation appears to be a good method for mitigating any deleterious effects, as indicated by the birth of at least one infant in a recent study cohort after using cryopreserved semen. Many men with sickle cell disease experience reproductive health issues. Pubertal delay is linked to...

In sickle cell anemia, red blood cells have a predominant role in the enhancement of phagocytic activity by mast cells, but in polycythemia vera, both cell types contribute to this phenomenon Stress erythropoiesis (SE) occurs when the physiological process of erythropoiesis is insufficient to fulfill the required production of functional red blood cells (RBCs), resulting...

Gain-of-function mutations in the PIEZO1 mechanosensor channel affect intracellular calcium concentration, affecting late-stage differentiation and disrupting apoptosis, hypoxia response, and glycolysis, according to a new study.  PIEZO1 is an important mechanosensitive cation channel that detects mechanical forces and is involved in many physiological functions. Its function in erythrocytes is to control hydration and cellular volume....

Iron deficiency impairs cognition, and a recent study found that those with hemoglobin < 10.0 g/dl scored more than one standard deviation below those with milder anemia. A hemoglobin level below 11 g/dl, considered moderate iron deficiency anemia (IDA), affects 1.5 percent of the U.S. population and is more common among minority groups. However, little...

Novel osmoscan-derived biomarkers Omin-width and Omax-width exhibited correlations with RDW, hyperchromic cells (Omax-width), OFT outcomes (Omin-width), and clinical severity in a monocenter retrospective cohort study. Hereditary spherocytosis (HS) is characterized by membrane instability of red blood cells (RBCs) and resultant instability and loss of the cell membrane due to pathogenic variants in genes involved in...

In adult patients with primary autoimmune hemolytic anemia (AIHA) undergoing rituximab treatment, there was a notable prevalence of hospitalizations due to infections, with a subsequent high mortality rate post-hospitalization, according to the results of a prospective study. The development of auto-antibodies against the red blood cells underlies the pathology of autoimmune hemolytic anemia (AIHA), which...

Sutimlimab is generally well tolerated, and the frequency and nature of treatment-emergent adverse events are consistent with those observed in elderly, medically complex patients, according to an analysis of data from two phase 3 studies. Cold agglutinin disease (CAD) is characterized by autoimmune hemolytic anemia mediated by the classical complement pathway. Sutimlimab, a monoclonal humanized...

The administration of zinc supplements proved to be effective in treating anemia, resulting in full recovery in 35% and a progressive increase in hemoglobin concentrations over the course of one year in chronic kidney disease patients with zinc deficiency and anemia, as reported in a retrospective study. Anemia in chronic kidney disease (CKD) is associated...

This preliminary study revealed that mice with certain genetic variants exhibit anemia, emphasizing the importance of LDHA in red blood cell erythropoiesis. Glycolysis, or the metabolism of glucose, is integral to cellular life. The pyruvate obtained in glycolysis is either converted to lactate or oxidized into the tricarboxylic acid cycle. The former process is catalyzed...