Breast Cancer

Clinical disparities are apparent in aggressive triple-negative breast cancer based on age and ethnicity. A recent study identifies unique epigenetic differences in triple-negative breast cancer tumors among younger African American women, suggesting potential clinical implications for diagnostics and treatment approaches. Younger African American women with triple-negative breast cancer exhibit distinct DNA methylation profiles. The unique...

Research reveals potential biological factors contributing to racial disparities in breast cancer mortality rates. MicroRNA-510-5p’s interaction with the scaffolding protein caveolin-1, specifically, could drive aggressive tumor growth and highlight potential reasons behind racial disparities in breast cancer outcomes. miR-510-5p’s regulation of caveolin-1 in fibroblasts potentially fuels aggressive tumor growth. Black women with breast cancer show...

Staff Writer: Andre McGowan A retrospective study found that axillary ultrasound falsely predicted nodal response to neoadjuvant systemic treatment in approximately half of node-positive breast cancer patients, which may result in the overtreatment of breast cancer patients. However, the interpretation of axillary ultrasound in luminal human epidermal growth factor receptor 2 negative cancer is useful...

Staff Writer: Andre McGowan Cell-free DNA is reported to be an authentic diagnostic biomarker in breast cancer patients. A recent study supports this, noting significantly increased levels of cell-free DNA in a group of breast cancer patients. Increased levels of cell-free deoxyribose nucleic acid (cfDNA) in cancer cells are associated with a reduction in the...

Staff Writer: Andre McGowan Although relative dose intensity similar, pathologic complete response higher with intervention A home-based diet and exercise intervention could improve outcomes for women undergoing chemotherapy for breast cancer, according to a study published online Sept. 1 in the Journal of Clinical Oncology. Tara Sanft, M.D., from Yale University in New Haven, Connecticut, and...

Diagnostic performance comparable for two test sets from the Personal Performance in Mammographic Screening scheme. Diagnostic performance of an artificial intelligence (AI) algorithm is comparable to human reader performance for interpreting mammographic screening, according to a study published online Sept. 5 in Radiology. Yan Chen, Ph.D., from the University of Nottingham in the United Kingdom,...

Possible higher risk of recurrence in association with drinking seen for women with lower body mass index. For women with breast cancer with higher body mass index (BMI), alcohol drinking is associated with a lower risk of overall mortality, according to a study published online Aug. 9 in Cancer. Marilyn L. Kwan, Ph.D., from Kaiser...

Dexamethasone decreases the incidence of docetaxel-induced oral mucositis in patients suffering from breast cancer in a dose-dependent manner. Pharmaceutical formulations containing docetaxel, an effective chemotherapeutic agent for the treatment of breast cancer, commonly lead to the development of oral mucositis (OM). To prevent the fluid retention that is associated with docataxel use in breast cancer...

Psychologically vulnerable breast cancer patients with less education, low social support, low patient activation, and younger age benefited most from nurse navigation intervention. Breast cancer patients with high levels of distress at the time of diagnosis tend to be at risk for physical symptoms and long-term distress. This randomized controlled trial (RCT) evaluated whether breast...