Lupus

A recent study highlights the potential of Janus kinase inhibitors in treating systemic lupus erythematosus by targeting specific molecular pathways and improving traditional treatment strategies. Janus kinase inhibitors target Janus kinase signal transduction and transcriptional activator pathway, which plays a central role in inflammation in systemic lupus erythematosus inflammation. Janus kinase inhibitors may improve systemic...

Anifrolumab treatment leads to earlier and more frequent attainment of lupus low disease activity state in patients with systemic lupus erythematosus. This suggests the potential for the drug to be incorporated into a treat-to-target approach for managing systemic lupus erythematosus patients. Anifrolumab increases lupus low disease activity state attainment in patients with systemic lupus erythematosus....

NMOSD impacts the eyes, spinal cord, and brain. It is a rare autoimmune neurological disorder that can cause severe disabilities such as blindness and paralysis. It often coexists with other autoimmune diseases such as lupus, Sjogren’s syndrome, or rheumatoid arthritis. Neuromyelitis Optica Spectrum Disorder (NMOSD) is a debilitating autoimmune disorder that affects the optic nerves,...

The presence of anti-DFS70 antibodies appears to be strongly linked to atopic dermatitis and may be a factor in the incorrect diagnosis of connective tissue disease. Connective tissue disease (CTD) is an umbrella term for a group of autoimmune disorders that affect connective tissues in the body, including joints, skin, and muscles. This study, published...

There is a causal association between autoimmune thyroid disease, systemic lupus erythematosus, Sjogren’s syndrome, and an increased risk of neuromyelitis optica spectrum disorder (NMOSD). Certain biological processes and signaling pathways may be involved in developing NMOSD in the presence of these autoimmune diseases. NMOSD is a disease that affects the central nervous system and can...

Low-dose IL-2 treatment may provide a new option for patients with chronic spontaneous urticaria who do not respond to traditional therapies. Chronic spontaneous urticaria (CSU) can significantly impact patients’ quality of life, and a substantial proportion remains unresponsive to traditional therapies. While second-generation H1-antihistamines are the first-line treatment, they may only be effective for some...

A retrospective study found that Black patients with vitiligo have high rates of comorbid autoimmune diseases. Vitiligo is a condition that causes loss of skin color in patches that can get larger over time. A 2020 retrospective study examined the diseases associated with vitiligo in the New York City population.  The researchers evaluated the data...

The role of dsDNA in the cerebrospinal fluid of patients with NMOSD is not fully understood, but researchers have found that the levels are higher in this population. Neuromyelitis optica spectrum disorder (NMOSD) causes inflammation in the central nervous system and results in severe myelitis and optic neuritis. Double-stranded DNA (dsDNA) has been found to...

The role of dsDNA in the cerebrospinal fluid of patients with NMOSD is not fully understood, but researchers have found that the levels are higher in this population. Neuromyelitis optica spectrum disorder (NMOSD) causes inflammation in the central nervous system and results in severe myelitis and optic neuritis. Double-stranded DNA (dsDNA) has been found to...