Hematology

As additional treatments for painful crises in juvenile sickle cell disease, vitamin D and omega-3 could result in overall cost savings and therapeutic benefits. Painful crises are the most prevalent complication of sickle cell disease (SCD). Omega-3 and vitamin D were found to have a possible therapeutic effect on painful crises. This research was published...

In terms of pain relief, the ketamine-based regimen was not determined to be superior to the morphine-based regimen. Nevertheless, ketamine therapy was related to a considerable decrease in cumulative opioid dose. Sickle cell disease (SCD) is an inherited hematologic illness in which deoxygenated hemoglobin polymerizes, causing red blood cells to assume a sickle-like shape. These...

iCanCope is a digital pain self-management platform that helps patients and caregivers easily manage pain episodes. It has been shown to help reduce the frequency and severity of SCD pain episodes. In addition, it can also help improve the quality of life for both patients and caregivers. Sickle cell disease (SCD) is a group of...

Patients with sickle cell anemia (SCA) may be protected from severe disease with malaria. However, severe complications, such as severe drops in hemoglobin, may occur in SCA patients with concomitant low-density malarial infection. Sickle cell anemia (SCA) has historically been linked to high levels of childhood mortality in Africa, with malaria playing a significant role....

L-glutamine is an FDA-approved treatment for sickle cell disease. One study explored the potential benefits and mechanism of action of L-glutamine in sickle cell disease patients. Leukocytosis is common in sickle cell disease (SCD) in the absence of infection and is a predictor for increased risk of stroke, acute chest syndrome, and mortality. Oral L-glutamine...

Supplementation with omega-3 or vitamin D may be useful for preventing and treating pain in patients with SCD. One study assessed the effects of supplementation in conjunction with standard therapy. A common clinical feature present in sickle cell disease (SCD) is pain caused by the distortion of red blood cells and the subsequent blocking of...

Children and youth with sickle cell disease (SCD) can benefit from digital interventions for self management of their disease. One study assessed the engagement and usefulness of a digital intervention in youth with SCD. Sickle cell disease (SCD) is marked by episodes of sudden, severe pain and increased risk for chronic pain. A digital platform...

Typically, monthly blood transfusion therapy is an option for children with sickle cell anemia (SCA) followed by hydroxyurea therapy. As blood transfusion therapy is not feasible in Africa, different strategies were investigated for stroke prevention in SCA. Stroke risk in children with sickle cell anemia (SCA) is 100 times times that for children without SCA,...

Advances in gene therapies and drug development have led to a resurgence in research for more effective sickle cell anemia treatments. This article discusses stem cell transplant options and avenues of drug development. Sickle cell anemia (SCA) results from a point mutation in the gene for the beta globin chain of hemglobin. After delivering oxygen,...