fbpx Skip to main content

Uterine leiomyomata (UL) are commonly known as fibroids and are the most common pelvic tumor in women. They are benign, smooth muscle tumors that arise from one muscle cell and thus the tumor is multiple clones of one cell. By 50 years of age, 70% of white women and 80% of black women have had at least one fibroid.

Fifteen to 30% of women develop severe symptoms, such as abdominal pain, abnormal menstrual bleeding, urinary incontinence, and fertility impairment. Uterine fibroids are the primary reason for a hysterectomy in the United States. In addition, they contribute to a decreased quality of life for many women.

  • Black women are disproportionately affected by UL compared to other racial groups.
  • Black women are also diagnosed at a younger age with fibroids.
  • Uterine fibroids are significantly larger at the time of diagnosis in black women compared to white women
  • Are associated with longer phases of sustained growth.
  • Tend to be genetic

Approximately 40% of uterine fibroids are chromosomally abnormal.

The aim of this case series of 75 self-reported black women with UL (who underwent surgery) is to present clinical, pathologic, cytogenetic, and select molecular profiles (MED12 mutation analysis.

There is evidence of racial differences for fibroid development on a molecular level, a discovery that may help guide treatment. In 2013, Moorman et al. in their analysis of 225 black and 135 white women yielded similar results to our study except that our study found a greater mean number of fibroids per patient (18.2 versus 9.9) as well as a greater uterine weight (591.9 g versus 477).

You May Also Like::  Home Visits Reduce Medicaid Costs in Pediatric Asthma Patients

Thirty-one percent of women in our study had fibroids with cytogenetic abnormalities, while 17.4% of all analyzed tumors were cytogenetically abnormal. However, this study did not show a relationship between cytogenetic abnormality and race that contributed to a specific morbidity. One specific genetic finding in this study was associated with UL in black and white women of short stature.

“Keeping up with the indications and adverse reactions to immune checkpoint inhibitors can be a full-time job. Cutaneous side effects occur in up to 45% of patients treated with ipilimumab and 34% of patients treated with nivolumab and pembrolizumab.” https://bit.ly/3FGtxtd

.@spfnomt: This month’s #DermWorld article “Estate planning 101” is especially important for young physicians to read. The long, all-consuming years between adolescence and physicianhood can become a blur...https://bit.ly/3FxOtCv

That’s a wrap #AAD2023! 5 days of soaking up knowledge from dermatologists on topics such as hidradenitis, melasma, & dietary triggers of common dermatoses.

I LOVED the #womenshealth focused sessions on vulvar dermatoses and pregnancy medication safety.


New approach uses microbiome to treat skin disease by repairing the injured microbiome that allowed inflammation to flare up in the first place, rather than reducing the inflammation after the fact. https://bit.ly/3Jt6H9v

Load More