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Findings seen among poor surgical candidates, with recurrence risk of 10 percent seen at 16 months Cryoablation can be performed effectively in nonsurgical breast cancer patients with varying tumors, according to a study presented at the annual meeting of the Society of Interventional Radiology, held from March 23 to 28 in Salt Lake City. Jolie...

In a phase III study, the administration of pembrolizumab with chemotherapy provided progression-free survival and overall survival benefits with a satisfactory safety profile compared to placebo in previously untreated patients with metastatic squamous non-small-cell lung cancer. The KEYNOTE-407 phase III study assessed the long-term survival outcomes in metastatic squamous non-small-cell lung cancer (NSCLC) patients treated...

Trastuzumab deruxtecan demonstrated an acceptable safety profile and was associated with a clinically significant objective response rate in patients with HER2-mutant metastatic non-small-cell lung cancer in a phase II study. Human epidermal growth factor receptor (HER2) mutations are present in a small number of non-squamous non-small-cell lung cancer (NSCLC) patients. Trastuzumab deruxtecan (T-DXd) is approved...

A cohort study finds that histologic subtype is the main factor associated with survival disparities between Black and White uterine cancer patients. Survival disparities have existed between non-Hispanic Black and White uterine cancer patients for decades, with an increased likelihood of aggressive disease, recurrence, and death among Black patients.  A cohort study published in JAMA...

But increase in cardiovascular disease mortality seen after more than 20 years of follow-up among older women For postmenopausal women, calcium and vitamin D (CaD) supplements may reduce cancer mortality and increase cardiovascular disease (CVD) mortality after more than 20 years of follow-up, according to a study published online March 12 in the Annals of Internal...

In the IDEA trial, postmenopausal patients aged 50–69 years with pT1N0 unifocal invasive breast cancer who did not receive radiotherapy achieved a high level of disease control after 5 years. For over three decades, radiotherapy has been an essential part of the treatment following breast-conserving surgery (BCS) for patients with early-stage breast cancer. Recent studies...

by Roger Mosley A retrospective cohort study analyzing a large dataset found that atopic dermatitis is associated with a significant increase in the risk of various skin cancer types. Atopic dermatitis (AD) causes scaly, itchy patches and is relatively benign. Although its pathogenesis is not fully understood, it is known that disruption in skin barrier...

In a retrospective cohort study, racial disparities in the use of medications and interventions near end of life were observed among patients with advanced gynecologic cancer.  Palliative medicine improves outcomes in patients with gynecologic malignancies. Studies on palliative medicine in cancer have minimal representation from minority groups. A retrospective cohort study published in the journal...

DRL-Trastuzumab was found to have similar efficacy, safety, pharmacokinetics, and immunogenicity as Herceptin in HER2-positive breast cancer patients in a randomized, double-blind study. Trastuzumab, marketed under the brand name Herceptin, is a standard therapy for human epidermal growth factor receptor 2 (HER2)-positive breast cancer. The drug DRL_TZ, a potential trastuzumab biosimilar to Herceptin, was developed...

Intermittent relacorilant + nab-paclitaxel improves survival outcomes and response duration in platinum-resistant/refractory ovarian cancer compared to nab-paclitaxel monotherapy, according to the results of a phase II study. Treatment of advanced epithelial ovarian cancer is challenging. Most patients who initially respond to platinum-based chemotherapy eventually develop resistance. Patient outcomes are poor in platinum-resistant/refractory ovarian cancer treated...