Search

Gynecological cancer uniquely affects health-related quality of life. A 2023 literature review reports that treatment side effects such as fatigue, pain, and sexual dysfunction impact psychological well-being. Younger patients and those in advanced stages generally experience greater challenges. Tailoring treatment approaches and implementing supportive care can help improve health-related quality of life for survivors. Gynecological...

A small cohort study found that p53 null mutations confer a particularly severe prognosis in high-grade serous ovarian cancers. Epithelial ovarian cancer is the fifth most common cause of female cancer-related mortality in the developed world. The most frequent type of epithelial ovarian cancer is high-grade serous ovarian cancer (HGSOC).  A cohort study published in...

A phase III study suggests that olaparib-bevacizumab is not only effective for high-risk (of relapse) HRD-positive tumors but is even more effective for low-risk patients in prolonging progression-free survival. Cure is the ultimate goal of ovarian cancer treatment; however, ovarian cancer patients are often first diagnosed at advanced stages, with an increased risk of relapse....

The phase 2 DAISY trial confirms that T-DXd efficacy depends on HER2 expression in breast cancer cases. However, it shows that T-DXd also has moderate activity in HER2-non-expressing patients, suggesting an alternative mechanism of action. Breast cancer is among the five most common causes of cancer mortality. Despite improvements in its treatment, 5-year survival rates...

by Deileta Kamhunga Post-surgical circulating tumor DNA detection is predictive of poor recurrence-free survival in stage I endometrial cancer patients, according to a recent retrospective analysis. Endometrial cancer (EC) is the most common gynecologic malignancy of the female reproductive tract. Circulating tumor DNA (ctDNA), a blood-based biomarker, predicts disease outcomes and detects molecular relapse ahead...

Reductions in cancer mortality being threatened by increasing incidence for six of top 10 cancers Cancer mortality is decreasing, but progress is being hampered by increasing incidence of some cancers, according to a study published online Jan. 17 in CA: A Cancer Journal for Clinicians. Rebecca L. Siegel, M.P.H., from the American Cancer Society in Atlanta,...

In this MD Newsline exclusive interview with oncologist Dr. Onyemaechi Okolo, we discuss cancer survival and cancer mortality among Black Americans. We also discuss how a patient’s socioeconomic status and education level impact their cancer management. MD Newsline: Why do Black Americans have the highest mortality rate and shortest survival of any racial/ethnic group in...

A type of signalling molecule called filamin A may play a key role in the battle against triple-negative breast cancer. This research could lead to more personalized and effective treatments by targeting the unique ways filamin A influences cancer growth and spread, offering new hope for those affected by this type of cancer, which is...

How much does where your patients live affect their cancer risk? Apparently a lot. While the mechanisms are complex, studies show geography affects a number of factors that can lead to higher incidence and worse outcomes of various cancer types.  Rural living is one of the many contexts in which geography affects risk. While rural...

A preliminary study reveals that tiny particles released by cancer cells may predict the effectiveness of breast cancer treatment, particularly for those facing triple-negative breast cancer. This research offers a promising approach to personalizing treatment plans, potentially improving outcomes for patients and providing new hope to individuals and their families navigating this challenging diagnosis. Dealing...