Cardiology

Evinacumab was found to be safe and well-tolerated and was associated with a sustained reduction in the levels of low-density lipoprotein cholesterol in patients diagnosed with refractory hypercholesterolemia. Individuals diagnosed with refractory hypercholesterolemia do not achieve the target levels of low-density lipoprotein cholesterol (LDL-C) despite lipid-lowering treatment at maximally tolerated dosages. These refractory hypercholesterolemia patients...

For the strategy of targeting low-density lipoprotein cholesterol to less than 70 mg/dL, patients with >50% reduction from baseline but not patients with <50% reduction from baseline showed superior stroke risk reduction when compared to a target level of 100 ± 10 mg/dL. The Treat Stroke-to-Target (TST) trial findings indicate the superiority of targeting low-density...

The trough plasma concentration of atorvastatin metabolites has a moderate correlation with a decrease in the levels of low-density lipoprotein cholesterol, according to the results of a randomized double‐blind crossover trial. Atorvastatin metabolites hold potential value in monitoring and optimizing the drug dosage for optimal clinical efficacy.    Statins form the standard treatment in the primary...

Rosuvastatin and atorvastatin were comparable in terms of all-cause death, coronary revascularization, myocardial infarction, or stroke at 3 years of intervention in a randomized prospective trial. However, rosuvastatin administration was related to comparatively lower levels of low-density lipoprotein cholesterol and a higher risk for cataract surgery and antidiabetic treatment. Statins are known to be effective...

Compared to a healthy omnivorous diet, a healthy vegan diet was associated with improved cardiometabolic parameters, including decreases in low-density lipoprotein cholesterol levels, fasting insulin levels, and body weight in an 8-week study of identical twins. Dietary patterns with high plant-based and low animal-based foods are associated with positive health and environmental outcomes. A well-formulated...

The 3-year composite of death, myocardial infarction, coronary revascularization, and stroke outcomes were comparable between treat-to-target and high-intensity statins in coronary artery disease patients in a recent randomized trial. Coronary artery disease (CAD) is associated with an increased risk for adverse cardiovascular events. Studies have recommended statin therapy for reducing the levels of low-density lipoprotein...

Yet prescription rates remain substantially lower than that seen for other guideline-recommended cardiometabolic therapies Barriers for proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9i) use persist for cholesterol management, according to a research letter published online Feb. 16 in Circulation: Cardiovascular Quality and Outcomes. Diane E. MacDougall, from the Family Heart Foundation in Fernandina Beach, Florida, and...

This randomized controlled trial demonstrated a lack of any significant differences in changes in cardiovascular disease risk factors (blood pressure and lipid levels) and weight loss among African Americans randomized to omnivorous or plant-based diets, both emphasizing soul food cuisine. Cardiovascular disease is associated with a higher mortality rate among African Americans than are other...

Authors say benefits include lower risk and cost, plus information on extent of coronary atherosclerosis A “computed tomography (CT)-first” strategy may be the best way to determine if stable chest pain patients need revascularization, according to a study presented at the American College of Cardiology Cardiovascular Summit 2024, which took place Feb. 1 to 3...