August 12, 2022

Transthyretin (TTR) gene variants may increase the risk of heart failure and other cardiac complications. A specific TTR gene variant at position 122 (V142I) is particularly common among middle-aged Black patients. The TTR V142I variant is characterized by a valine-to-isoleucine substitution and is a significant cause of cardiac amyloidosis. Although research is ongoing, one particular...