Heart Failure

A recent study examined how frequently the V122I genetic variant leads to heart failure in older Black individuals. This research sought to identify how specific genes can influence the development and presentation of transthyretin amyloid cardiomyopathy. Transthyretin amyloid cardiomyopathy (ATTR-CM) remains an underdiagnosed cause of heart failure among older individuals. The V122I variant, associated with...

Heart disease is a terrifying medical issue that kills around 697,000 Americans each year. Because of this, preventing heart disease is a top issue for many.  However, the possibility of a genetic condition adds a hurdle to this. If heart disease is genetic, can it truly be managed?  This article will explore the genetic nature...

Transthyretin (TTR) gene variants may increase the risk of heart failure and other cardiac complications. A specific TTR gene variant at position 122 (V142I) is particularly common among middle-aged Black patients. The TTR V142I variant is characterized by a valine-to-isoleucine substitution and is a significant cause of cardiac amyloidosis. Although research is ongoing, one particular...

Among patients with an acute heart failure exacerbation, treatment with colchicine for a gout flare is associated with significantly lower in-hospital mortality, according to a study published in Clinical Cardiology. Mary E. Roth, Pharm.D., from the University of Virginia Health in Charlottesville, and colleagues used data for 1,047 patients hospitalized with acute heart failure (March...

For patients with type 2 diabetes (T2D) receiving first-line sodium-glucose cotransporter-2 inhibitors (SGLT-2i), the risk for stroke, myocardial infarction (MI), and all-cause mortality is similar to those receiving metformin, and the risk for hospitalization for heart failure (HHF) is lower, according to a study published in the Annals of Internal Medicine. HoJin Shin, Ph.D., from...

But widening geographic disparities observed, mostly accounted for by within-state differences The rate of premature cardiac deaths (PCDs) decreased across U.S. counties from 1999 to 2017, although widening geographic disparities have been observed, according to a study published online July 29 in the Journal of the American Heart Association. Yinzi Jin, Ph.D., from the Peking...

Substantial and increasing disparities found between highest resource group and remainder of population There are substantial and increasing disparities in the prevalence of cardiovascular disease (CVD) among the highest-resource group and the remainder of the U.S. population, according to a study published online Sept. 25 in JAMA Network Open. Salma M. Abdalla, M.B.B.S., M.P.H., from...

Poor health literacy is associated with worse heart failure outcomes, according to a review published in the June issue of JACC: Heart Failure. Matteo Fabbri, M.D., from the Mayo Clinic in Rochester, Minnesota, and colleagues conducted a systematic literature review to evaluate associations between health literacy and health-related outcomes in patients with heart failure. Based on...

Prediabetes is associated with an increased risk for all-cause mortality and cardiovascular disease among the general population and individuals with atherosclerotic cardiovascular disease, according to a meta-analysis published online July 15 in The BMJ. Xiaoyan Cai, from Southern Medical University in Foshan, China, and colleagues conducted an updated meta-analysis to assess the associations between prediabetes and...