Tracey Roizman

Research indicates significant alterations in the gut microbiota of chronic spontaneous urticaria patients, characterized by reduced diversity, lower levels of SCFA-producing bacteria, and increased pathogenic bacteria. Chronic spontaneous urticaria (CSU) is the most common type of chronic urticaria (CU), often lasting for a few years despite intensive medical treatment. Moreover, relapse rates for the condition...

A recent randomized controlled trial shows that patients who do not respond to initial therapy with nonsedating H1-antihistamines might respond to these drugs when given at four-fold higher dosages. Urticaria is a common dermatological condition that can be acute or chronic. Chronic urticaria (CU) persists for more than 6 weeks and requires frequent healthcare visits,...

Chronic spontaneous urticaria (CSU) presents treatment challenges, with 61% unresponsive to antihistamines. The findings of a recent literature review reveal the pivotal role of mast cells and identify two autoimmune responses as potential targets of new treatment approaches. Chronic spontaneous urticaria (CSU) is a common, poorly understood immunological disease. Skin infestations, like recurrent wheals and...

The apolipoprotein B/A1 ratio can be used to predict the amount of tissue prolapse seen on an optical coherence tomography scan, and it is linked to how easily the apolipoprotein B/A1 plaque can break, according to a recent single-center, cross-sectional analysis. The apolipoprotein (Apo) B/A1 ratio is considered a reliable predictor of atherosclerotic cardiovascular disease....

An analysis of cohort data from the Multi-Ethnic Study of Atherosclerosis database found that elevated remnant cholesterol is a residual risk factor for aortic valve calcium progression, regardless of the conventional cardiovascular risk factors. Aortic valve calcium (AVC) is associated with the development of calcific aortic valve disease, which is one of the leading causes...

Children from marginalized groups less likely to receive screening, more likely to be referred for failed screening, less likely to establish care with a specialist Gaps in access to childhood vision screening and vision care are prevalent among historically marginalized racial and ethnic groups and socioeconomically vulnerable families, according to a research letter published online...

Severely immunocompromised individuals had greater SARS-CoV-2 evolution, higher risk for developing resistance against therapeutic mAbs The risk for prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) varies across immunosuppressive conditions, according to a study published in the Jan. 24 issue of Science Translational Medicine. Yijia Li, M.D., from Harvard Medical School in Boston, and colleagues performed...

Increases seen in suicidal thoughts, depressive or anxiety symptoms, and inattention or hyperactivity Adolescent substance use is associated with psychiatric symptoms, including suicidal thoughts, according to a research letter published online Jan. 29 in JAMA Pediatrics. Brenden Tervo-Clemmens, Ph.D., from the University of Minnesota in Minneapolis, and colleagues examined associations between commonly used substances and psychiatric...

Significant improvement seen in overall survival with pembrolizumab versus placebo and across key subgroups For patients with clear-cell renal cell carcinoma (ccRCC), overall survival (OS) is improved for those receiving pembrolizumab versus placebo at a median follow-up of about 57 months, according to a study presented at the American Society of Clinical Oncology annual Genitourinary...