Tracey Roizman

The deregulation of ubiquitin-specific protease 7 activity increased DNA replication stress in an in vitro study, which was found to disrupt the DNA repair process during the S phase of the cell cycle. Aberrant expression of ubiquitin-specific protease 7 (USP7), a deubiquitinating enzyme, is involved in tumor progression. This is due to altered DNA damage...

Saraca asoca methanol bark extract had a selective anticancer effect on the estrogen-receptor subtype of triple-negative breast cancer in a cell culture study. The anticancer effects were attributed to phytoestrogens in the methanol bark extract, particularly quercetin. Saraca asoca has been found to have anticancer effects related to the presence of phytoestrogens in the methanol...

17ß-estradiol promotes metastasis in patients with triple-negative breast cancer. A cell culture and mouse model study demonstrated that this process may be mediated by the calpain/YAP/ß-catenin signaling axis. The absence of estrogen and progesterone receptors and human epidermal growth factor receptor-2 characterizes triple-negative breast cancer (TNBC) cells. The estrogen 17ß-estradiol, or E2, promotes the proliferation...

The type of adjuvant systemic therapy has an impact on Edmonton Symptom Assessment System scores in patients with breast cancer, as reported in a recent retrospective analysis. Triple-negative tumor histology and the outcomes of previous neoadjuvant treatment were related to symptom burden. Multimodal treatment in breast cancer patients can have side effects, as reported in...

Salvianolic acid A, an anti-cancer agent, showed a potential effect on M2 tumor-associated macrophages in a cell culture study, which concluded that it may be useful for reprogramming these macrophages in the management of triple-negative breast cancer. Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with challenging management and a poor prognosis....

Increased mortality risks seen for five major adverse pregnancy outcomes; further increases seen with multiple adverse outcomes Women who experience any of five major adverse pregnancy outcomes have increased mortality risks, which remain elevated during long-term follow-up, according to a study published online April 15 in JAMA Internal Medicine. Casey Crump, M.D., Ph.D., from the University...

Substance use disorder was most commonly seen The majority of people experiencing homelessness have mental health disorders, according to a review published online April 17 in JAMA Psychiatry. Rebecca Barry, Ph.D., from the Cumming School of Medicine at the University of Calgary in Alberta, Canada, and colleagues conducted a systematic literature review and meta-analyses to examine...

Participants in a high versus low routine task intensity group had higher risk for MCI and dementia Individuals with a history of cognitively stimulating occupations from ages 30 to 65 years have lower risk for mild cognitive impairment (MCI) and dementia in later life, according to a study published online April 17 in Neurology. Trine H....

Substance use disorder was most commonly seen The majority of people experiencing homelessness have mental health disorders, according to a review published online April 17 in JAMA Psychiatry. Rebecca Barry, Ph.D., from the Cumming School of Medicine at the University of Calgary in Alberta, Canada, and colleagues conducted a systematic literature review and meta-analyses to examine...