Tracey Roizman

An analysis of microarray data demonstrated impaired apoptosis signaling pathways in CD14+ monocytes in psoriatic arthritis patients, concluding that their increased levels may play an essential role in the disease pathogenesis. Psoriatic arthritis (PsA) is a complex chronic inflammatory condition affecting approximately 30% of patients with psoriasis, leading to functional impairments and increased mortality risk. ...

A prospective follow-up study found that psoriatic arthritis patients with higher synovial immunohistochemical reactivity of IL-17A, DKK1, and TGF-β1 are more likely to benefit from early initiation of biologics. Psoriatic arthritis (PsA) is a chronic inflammatory disease affecting joints and skin in patients with psoriasis. It exhibits progressive and destructive joint changes, with significant pathological...

Although psoriatic arthritis activity indices might suggest disease severity, this retrospective study demonstrated that disease activity levels and severity are two different concepts and not essentially interchangeable. Psoriatic arthritis (PsA) is a complex, chronic, multidomain inflammatory disease. There have been many studies and indices focusing on identifying and classifying disease activity levels. However, much less...

M1 polarization of macrophages and their dynamic crosstalk with other cells, such as fibroblasts and lymphocytes, may explain the pathogenesis of hidradenitis suppurativa, providing new therapeutic strategies. Hidradenitis suppurativa (HS) is a chronic inflammatory dermatological condition involving the perianal, axillary, inguinal, and gluteal areas of the body. The disease pathogenesis is based on the dysregulation...

A systematic review reports that the drug survival of biologics in hidradenitis suppurativa is comparatively shorter than that of biologics for other dermatological conditions. Drug survival is a measure of the tolerability and efficacy of different treatment regimens. It is described by the proportion of patients who remain on the given treatment regimen over a...

Patients with hidradenitis suppurativa were found to have a significantly increased risk of periodontitis compared to both healthy controls and psoriasis patients in a retrospective cohort study. Hidradenitis suppurativa (HS) is characterized by chronic inflammation of the skin, accompanied by systemic symptoms. HS is associated with comorbid conditions in other organ systems. Periodontitis is an...

Chronic spontaneous and inducible urticaria significantly affect work productivity and quality of work, particularly when the conditions remain undiagnosed or poorly controlled, according to the findings of a new prospective study. Chronic urticaria is characterized by erythemato-papular rash associated with transient angioedema. Chronic spontaneous urticaria (CSU) or chronic inducible urticaria (CIndU) has a considerable impact...

A randomized controlled trial reports that Ziziphus jujube syrup was an effective add-on treatment for a group of patients with chronic spontaneous urticaria resistant to standard second-generation H1 antihistamines. Chronic spontaneous urticaria (CSU) is an intermittent condition characterized by urticaria and/or angioedema lasting for a minimum of 6 weeks. The first-line management of CSU includes...

Bepotastine besilate was found to have comparatively greater efficacy than levocetirizine for reducing mean urticaria activity score and improving quality of life in chronic spontaneous urticaria patients in an interventional study. Chronic spontaneous urticaria (CSU) affects approximately 15–20% of the population at least once during their lifetime. Antihistamines comprise the cornerstone treatment approach for this...