Tracey Roizman

A preliminary clinical trial suggests that topical rosuvastatin or melatonin are effective at controlling psoriatic skin rashes, with significant benefits reported on days 30 and 60. Psoriasis, a chronic inflammatory skin disorder affecting about 3% of the population, typically manifests in adolescence or later adulthood. The most common form is chronic plaque psoriasis, characterized by...

A new clinical study shows that tildrakizumab effectively improves the quality of life and enhances the work productivity of those living with psoriasis. Psoriasis is a prevalent chronic inflammatory disorder affecting about 3% of US individuals aged 20 and older, making it a significant immune-mediated disease in the US. The economic burden of psoriasis is...

An updated review highlights the role of dysregulated adipokines in cardiovascular comorbidities in psoriasis and finds that biologics exert a cardioprotective role in some cases. Psoriasis is a prevalent chronic, inflammatory, multi-organ, systemic disease affecting millions worldwide. Its most common form, plaque psoriasis, manifests as erythematous plaques with silvery scales, notably on the elbows, knees,...

An analysis of microarray data demonstrated impaired apoptosis signaling pathways in CD14+ monocytes in psoriatic arthritis patients, concluding that their increased levels may play an essential role in the disease pathogenesis. Psoriatic arthritis (PsA) is a complex chronic inflammatory condition affecting approximately 30% of patients with psoriasis, leading to functional impairments and increased mortality risk. ...

A prospective follow-up study found that psoriatic arthritis patients with higher synovial immunohistochemical reactivity of IL-17A, DKK1, and TGF-β1 are more likely to benefit from early initiation of biologics. Psoriatic arthritis (PsA) is a chronic inflammatory disease affecting joints and skin in patients with psoriasis. It exhibits progressive and destructive joint changes, with significant pathological...

Although psoriatic arthritis activity indices might suggest disease severity, this retrospective study demonstrated that disease activity levels and severity are two different concepts and not essentially interchangeable. Psoriatic arthritis (PsA) is a complex, chronic, multidomain inflammatory disease. There have been many studies and indices focusing on identifying and classifying disease activity levels. However, much less...

M1 polarization of macrophages and their dynamic crosstalk with other cells, such as fibroblasts and lymphocytes, may explain the pathogenesis of hidradenitis suppurativa, providing new therapeutic strategies. Hidradenitis suppurativa (HS) is a chronic inflammatory dermatological condition involving the perianal, axillary, inguinal, and gluteal areas of the body. The disease pathogenesis is based on the dysregulation...

A systematic review reports that the drug survival of biologics in hidradenitis suppurativa is comparatively shorter than that of biologics for other dermatological conditions. Drug survival is a measure of the tolerability and efficacy of different treatment regimens. It is described by the proportion of patients who remain on the given treatment regimen over a...

Patients with hidradenitis suppurativa were found to have a significantly increased risk of periodontitis compared to both healthy controls and psoriasis patients in a retrospective cohort study. Hidradenitis suppurativa (HS) is characterized by chronic inflammation of the skin, accompanied by systemic symptoms. HS is associated with comorbid conditions in other organ systems. Periodontitis is an...