Condition Center
Dr. Valerie Harvey: Vitiligo
In this MD Newsline exclusive interview with dermatologist Dr. Valerie Harvey, we discuss why vitiligo is an important health issue. MD Newsline: Can you explain why vitiligo is an important health issue? Dr. Valerie Harvey: “Vitiligo is a chronic autoimmune skin condition where your body’s immune system attacks the cells that make pigment in your...
Alopecia in African Americans
In this MD Newsline exclusive interview with dermatologist Dr. Valerie Harvey, we discuss the types of alopecia that are prevalent in African Americans: central centrifugal cicatricial alopecia (CCCA) and traction alopecia. MD Newsline: What types of alopecia have a high prevalence in African Americans? Dr. Valerie Harvey: “There are two types of alopecia that are...
The Oncogenic Role of COPB2 in Human Tumors
Coatomer protein complex subunit beta 2, also known as COPB2, may act as an oncogene in certain types of cancer. Until now, no systematic pan-cancer analysis has been performed on COPB2. This study, published in BioMed Research International, used The Cancer Genome Atlas and the Gene Expression Omnibus datasets to analyze the oncogenic role of COPB2. ...
Tumor Mutational Burden and Immunotherapy Response
Tumor mutational burden (TMB) can function as a biomarker for response to immunotherapy. Understanding how to accurately test TMB and understanding the implications of variation in the results can inform treatment. This study, published in Clinical Research (Excluding Clinical Trials), analyzed the genomic profiles of patients with cancer to assess TMB prevalence and variability, and its...
New Pan-Tumor Test Shows Promise
The PD-L1 IHC 22C3 pharmDx is an FDA-approved companion diagnostic to pembrolizumab designed for use on Autostainer Link 48. This study, published in Pathology, compared a 22C3 antibody-based laboratory-developed test (LDT) on BenchMark XT with the FDA-approved PD-L1 IHC 22C3 pharmDx. Pan-tumor data for this study included samples from a total of 327 patients with esophageal...
Incidence Rates of Pediatric Cancers Vary by Race, Ethnicity
Variation seen by single year of age, including lower incidence of acute lymphoblastic leukemia in Blacks, especially at 1 to 7, 16 to 20 years Incidence rates of pediatric cancers vary according to race and ethnicity, according to a study published online June 21 in Cancer. Erin L. Marcotte, Ph.D., from the University of Minnesota...
Could Gene Therapy Help Cure Sickle Cell Disease?
A gene therapy that could provide a permanent cure for sickle cell disease continues to show success through a third wave of patients, researchers report. The therapy, LentiGlobin, restored normal blood function in 35 sickle cell patients who had the one-time procedure, according to clinical trial findings published Dec. 12 in the New England Journal...
Risk of Stillbirth Up for Pregnant People With Sickle Cell Trait
In fully adjusted model, increased risk of stillbirth also seen for those with sickle cell disease, multiple gestations Pregnant people with sickle cell trait (SCT) have increased risk of stillbirth, according to a study published online Nov. 24 in JAMA Network Open. Silvia P. Canelón, Ph.D., from the University of Pennsylvania in Philadelphia, and colleagues...
ADHD Tied to Fourfold Higher Likelihood of Having Anxiety Disorder
Among those with ADHD, factors associated with GAD included being female and having low income, lifetime history of a mood disorder Adults with attention-deficit/hyperactivity disorder (ADHD) are at significantly higher risk for generalized anxiety disorder (GAD), according to a study published online Nov. 16 in the Journal of Affective Disorders. Esme Fuller-Thomson, Ph.D., from University...
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