Condition Center

A comprehensive workshop hosted by the International Agency for Research on Cancer and the National Cancer Institute highlights evolving patterns and research priorities in the relationship between HIV and cancer, offering new directions for managing these complex health challenges. Approximately 38 million people globally are living with HIV. This population is at increased risk for...

A recent review reveals significant impacts of social determinants like socioeconomic status, education, and geography on health outcomes for individuals with HIV and heart failure, emphasizing the need for holistic healthcare strategies. This insight may help in addressing complex health challenges and advancing integrated care approaches. A narrative review published in the journal Cureus delves...

A Mendelian randomization analysis study has demonstrated an increased risk of multiple myeloma in individuals genetically susceptible to primary sclerosing cholangitis. Multiple myeloma is a malignant proliferative disease with rapidly increasing incidence and mortality and a poor prognosis. Recent studies have highlighted the potential relationship between multiple myeloma and autoimmune diseases.  In this Mendelian randomization...

This case study highlights the need for a multidisciplinary approach for patient-targeted management in severe refractory cases of hypoglycemia in individuals with type 1 diabetes mellitus on insulin therapy. Key Points Hypoglycemia is a common complication of insulin therapy that increases the risk of developing cognitive impairment, cardiovascular complications, and hypoglycemia unawareness. There are no...

Initial decrease seen in proportion with inappropriate prescription, followed by subsequent increase There was an initial decrease in inappropriate antibiotic prescriptions following onset of COVID-19, followed by an increase, according to a study published online April 22 in Clinical Infectious Diseases. Kao-Ping Chua, M.D., Ph.D., from the University of Michigan Medical School in Ann Arbor, and...

Despite its rarity, this case of insulin allergy in gestational diabetes mellitus highlights the importance of its prompt recognition to ensure the safety of the mother and fetus. Key Points Most hypersensitivity reactions to insulin or its additives are immunoglobulin E (IgE)-mediated type I reactions. These allergic reactions occur with a relatively low frequency of...

While modern insulins and purification techniques have reduced the incidence of allergic reactions, some patients still experience them. This case highlights the success of Rituximab, a new approach, for a patient with severe and persistent reactions. Key Points: Before the 1970s, allergic reactions to insulin were quite common because of impurities found in insulin preparations...

A new prospective study found that both multiple sclerosis and neuromyelitis optica spectrum disorder lead to similar kinds of glymphatic impairments, despite etiological differences in the disease conditions. The glymphatic system, a recently recognized brain waste clearance system, plays a crucial role in maintaining brain health by facilitating the removal of waste products and maintaining...

Increased risk for all-cause mortality seen with postpartum young-onset breast cancer in women with germline BRCA pathogenic variants Young-onset breast cancer (YOBC) with germline BRCA pathogenic variants (PVs) is associated with an increased risk for all-cause mortality if diagnosed within 10 years after childbirth, according to a study published online April 19 in JAMA Network Open. Zhenzhen Zhang,...