Rheumatology

Risk for gout even higher in patients with Crohn disease and ulcerative colitis who undergo intestinal resection. Inflammatory bowel disease (IBD) is strongly associated with gout, according to a study published online Sept. 1 in JGH Open. Osama Hamid, M.B.B.S., from the Cleveland Clinic, and colleagues investigated the association between IBD and gout using data from...

Key Takeaways People with fibromyalgia are more likely to die early from accidents, infections and by suicide, new research suggests This condition often travels with other diseases and conditions, which can increase the risk of dying early Fatigue, concentration difficulties, depression and reduced immune function may all play a role in the findings For years,...

Findings for middle- and older-aged men and women. Higher levels of alcohol consumption could have detrimental effects on muscle mass in middle- and older-aged men and women, according to a study published online May 25 in Calcified Tissue International. Jane Skinner, Ph.D., from the University of East Anglia in the United Kingdom, and colleagues assessed...

Key Takeaways Older adults with autism can experience a host of physical and mental ills as they age, new research shows. They faced higher risks of heart failure, COPD, osteoarthritis, anemia, self-harm, type 2 diabetes, falls, spinal issues and gastrointestinal issues. But there was also a mental toll: Those with autism were susceptible to lower...

Increased serum, salivary, and urinary immunoglobulin gamma-3 chain C  levels are observed in systemic lupus erythematosus patients. Immunoglobulin gamma-3 chain C (IGHG3) is a type of IgG that plays a major role in the pathogenesis of systemic lupus erythematosus (SLE). It contributes to hypergammaglobulinemia and IgG immune complex deposition in tissues, leading to organ damage...

Increased antibodies to Epstein–Barr virus and cytomegalovirus in patients with drug-induced lupus indicate their contribution to the development of the disease. Epstein–Barr virus (EBV) and cytomegalovirus (CMV) are implicated in systemic lupus erythematosus (SLE) pathogenesis. Drug-induced lupus (DIL) is a lupus-like disease resulting from therapeutic drug intake. DIL represents approximately 10–15% of all lupus cases....

Recent research highlights the crucial role of noncoding RNAs in the pathogenesis of systemic lupus erythematosus, offering a deeper understanding of the disease and opening doors for targeted therapies. Noncoding RNAs, including microRNAs, long noncoding RNAs, and circular RNAs, contribute significantly to the pathogenesis of systemic lupus erythematosus. Dysregulation of noncoding RNAs can impact signaling...

A recent study highlights the potential of Janus kinase inhibitors in treating systemic lupus erythematosus by targeting specific molecular pathways and improving traditional treatment strategies. Janus kinase inhibitors target Janus kinase signal transduction and transcriptional activator pathway, which plays a central role in inflammation in systemic lupus erythematosus inflammation. Janus kinase inhibitors may improve systemic...

Anifrolumab treatment leads to earlier and more frequent attainment of lupus low disease activity state in patients with systemic lupus erythematosus. This suggests the potential for the drug to be incorporated into a treat-to-target approach for managing systemic lupus erythematosus patients. Anifrolumab increases lupus low disease activity state attainment in patients with systemic lupus erythematosus....