Pulmonology

Key Takeaways Older adults with autism can experience a host of physical and mental ills as they age, new research shows. They faced higher risks of heart failure, COPD, osteoarthritis, anemia, self-harm, type 2 diabetes, falls, spinal issues and gastrointestinal issues. But there was also a mental toll: Those with autism were susceptible to lower...

Dupilumab is effective in improving asthma outcomes in patients with coexisting chronic rhinosinusitis and nasal polyps, and it can reduce the need for oral corticosteroids and improve patients’ quality of life. People with asthma also experience chronic rhinosinusitis and nasal polyps  (CRS-NPs), and allergic rhinitis, and they have a higher disease burden and are more...

Ecleralimab administration is a safe intervention in patients suffering from mild atopic asthma, as it is effective in attenuating airway inflammation and allergen-induced bronchoconstriction. Thymic stromal lymphopoietin (TSLP) is an upstream regulator that mediates inflammatory responses, including type 2 inflammation in asthma. Ecleralimab is a neutralizing antibody fragment that works against human TSLP, and was...

Treatment with dupilumab, a monoclonal antibody, significantly improves clinical outcomes and mediates the reversal of persistent airflow obstruction status in patients with uncontrolled asthma. Asthma is associated with airflow obstruction, which is reversible either spontaneously or with the administration of bronchodilators or corticosteroids. Asthma patients with persistent airflow obstruction (PAO) tend to experience worse asthma...

While the Dyson high-efficiency particulate air purifier significantly improved air quality, the device did not yield any significant outcomes in lung function measures, asthma control, or quality of life, in this study. Emerging evidence supports the association between air pollution and poor asthma outcomes. While the efficacy of high-efficiency particulate air purifiers and related devices...

Omalizumab appears to be effective in reducing exacerbations and improving lung function, and it may also allow patients to reduce their inhaled corticosteroid dose. Asthma is a highly prevalent respiratory disease affecting millions of people globally. While asthma is typically considered a childhood-onset illness, onset during adolescence and adulthood is also possible. Early-onset asthma (ages...

Pomegranate extract supplementation improves spirometry test results in mild asthma patients Asthma is a complex respiratory disease affecting over 300 million people globally. It is caused by a combination of environmental exposure, genetic susceptibility, and host factors, leading to inflammation, airway obstruction, and excessive mucus production. Cytokines and inflammatory mediators contribute to airway inflammation, accompanied...

Length of stay is one way to determine the quality of care that patients have access to, and this study focuses on comparing length of stay across racial disparities for various pediatric conditions, including asthma. Inequities in childhood disease can manifest in a number of ways, and tend to be disparate across racial, ethnic, and...

Intravenous dexamethasone and methylprednisolone treatments for children with critical asthma in the PICU yielded no significant differences in clinical efficacy and safety. Dexamethasone may have potential advantages, such as a shorter corticosteroid exposure duration and less reliance on prescribed corticosteroids at discharge, which merit additional investigation. Childhood asthma affects approximately 5.1 million children in the...